The role of backward mutations on the within-host dynamics of HIV-1

DOI10.1007/S00285-012-0581-2zbMath1278.92028OpenAlexW1972912331WikidataQ37007926 ScholiaQ37007926MaRDI QIDQ378292

Roberto A. Saenz, John M. Kitayimbwa, Joseph Y. T. Mugisha

Publication date: 11 November 2013

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc4909148

zbMATH Keywords

drug resistancewithin-host modelvirus mutations

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Medical epidemiology (92C60)

Related Items (8)

Stochastic investigation of HIV infection and the emergence of drug resistance ⋮ Reducing the Latent CD4⁺Cells Reservoirs in HIV Infection with Optimal HAART Therapy ⋮ Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects ⋮ Global dynamics and cost-effectiveness analysis of HIV pre-exposure prophylaxis and structured treatment interruptions based on a multi-scale model ⋮ The impact of cell regeneration on the dynamics of viral coinfection ⋮ Estimation of the HIV-1 backward mutation rate from transmitted drug-resistant strains ⋮ The effects of CTL immune response on HIV infection model with potent therapy, latently infected cells and cell-to-cell viral transmission ⋮ DYNAMICAL BEHAVIORS OF AN INFLUENZA EPIDEMIC MODEL WITH VIRUS MUTATION

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• Emergence of HIV-1 drug resistance during antiretroviral treatment
• Drug concentration heterogeneity facilitates the evolution of drug resistance
• Production of resistant HIV mutants during antiretroviral therapy

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