Dissecting the dynamics of the Hes1 genetic oscillator

DOI10.1016/J.JTBI.2008.07.013zbMath1400.92194OpenAlexW2080757588WikidataQ44162969 ScholiaQ44162969MaRDI QIDQ1797715

Hiroshi Momiji, Nicholas A. M. Monk

Publication date: 22 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2008.07.013

zbMATH Keywords

negative feedbackdifferential stabilityHes1somitogenesisprotein dimerisationStat3transcriptional delay

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

Related Items (14)

D-leaping: accelerating stochastic simulation algorithms for reactions with delays ⋮ Intracellular protein dynamics as a mathematical problem ⋮ Computational modelling of cancer development and growth: modelling at multiple scales and multiscale modelling ⋮ Spatio-temporal models of synthetic genetic oscillators ⋮ Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways ⋮ Stability of delay induced oscillations in gene expression of Hes1 protein model ⋮ The role of dimerisation and nuclear transport in the Hes1 gene regulatory network ⋮ Molecular crosstalk: notch can manipulate Hes1 and miR-9 behavior ⋮ Spatial-stochastic modelling of synthetic gene regulatory networks ⋮ Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling ⋮ Oscillations in well-mixed, deterministic feedback systems: beyond ring oscillators ⋮ Hopf bifurcation in a gene regulatory network model: Molecular movement causes oscillations ⋮ Mathematical modeling of the intracellular protein dynamics: the importance of active transport along microtubules ⋮ Multistability and transitions between spatiotemporal patterns through versatile Notch-Hes signaling

Cites Work

• Unnamed Item
• Modelling periodic oscillations during somitogenesis
• Oscillations of Hes7 caused by negative autoregulation and ubiquitination
• Amplitude of circadian oscillations entrained by 24-h light-dark cycles
• Hopf bifurcation in a DDE model of gene expression
• Modelling transcriptional feedback loops: the role of Gro/TLE1 in Hes1 oscillations

This page was built for publication: Dissecting the dynamics of the Hes1 genetic oscillator