The role of dimerisation and nuclear transport in the Hes1 gene regulatory network

DOI10.1007/s11538-013-9842-5zbMath1297.92032OpenAlexW2105579799WikidataQ37723657 ScholiaQ37723657MaRDI QIDQ458692

Mark A. J. Chaplain, Andreas Hellander, Sahar Aldakheel, Marc Sturrock, Linda R. Petzold

Publication date: 8 October 2014

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc3999905

zbMATH Keywords

\texttt{URDME}dimerisationHes1nuclear transportspatial stochastic modelling

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37)

Related Items (8)

Local error estimates for adaptive simulation of the reaction-diffusion master equation via operator splitting ⋮ The influence of nuclear compartmentalisation on stochastic dynamics of self-repressing gene expression ⋮ Editorial: Special issue on stochastic modelling of reaction-diffusion processes in biology ⋮ Mean field analysis of a spatial stochastic model of a gene regulatory network ⋮ A 3D multiscale model to explore the role of EGFR overexpression in tumourigenesis ⋮ Mesoscopic Modeling of Stochastic Reaction-Diffusion Kinetics in the Subdiffusive Regime ⋮ Oscillations in well-mixed, deterministic feedback systems: beyond ring oscillators ⋮ Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network

Uses Software

• URDME
• Wavos

Cites Work

• Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
• A spatial model of cellular molecular trafficking including active transport along microtubules
• Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling
• Dissecting the dynamics of the Hes1 genetic oscillator
• Approximating intrinsic noise in continuous multispecies models
• Simulation of Stochastic Reaction-Diffusion Processes on Unstructured Meshes
• Modelling transcriptional feedback loops: the role of Gro/TLE1 in Hes1 oscillations
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