A 3D multiscale model to explore the role of EGFR overexpression in tumourigenesis

DOI10.1007/S11538-019-00607-YMaRDI QIDQ2002113zbMATH OpenOpenAlexWikidataFDO

Authors Anass Bouchnita, Stefan Hellander, Andreas Hellander

Publication date 11 July 2019

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/s11538-019-00607-y

zbMATH Keywords

Brownian dynamicstumour growthagent-based modellingEGFR

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15)

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Cites work

• A mathematical model of drug resistance: Heterogeneous tumors
• Chaste: A test-driven approach to software development for biological modelling
• Computational modelling of cancer development and growth: modelling at multiple scales and multiscale modelling
• Growth of necrotic tumors in the presence and absence of inhibitors
• Mathematical modeling of corneal epithelial wound healing
• Multiscale agent-based cancer modeling
• Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression
• The role of dimerisation and nuclear transport in the Hes1 gene regulatory network
• Three-dimensional multispecies nonlinear tumor growth. I: Model and numerical method

Cited in

(8)

• Mathematical modeling and analysis of ErbB3 and EGFR dimerization process for the gefitinib resistance
• Mathematical modelling of Her2 (ErbB2) PI3K/AKT signalling pathways during breast carcinogenesis to include PTPD2
• The effects of EGF-receptor density on multiscale tumor growth patterns
• An integrated agent-mathematical model of the effect of intercellular signalling via the epidermal growth factor receptor on cell proliferation
• Phenotype-structured model of intra-clonal heterogeneity and drug resistance in multiple myeloma
• Identifying therapeutic targets in a combined EGFR-TGF\(\beta\)R signalling cascade using a multiscale agent-based cancer model
• A multiscale model to design therapeutic strategies that overcome drug resistance to tyrosine kinase inhibitors in multiple myeloma
• Mathematical modeling of the dimerization of EGFR and ErbB3 in lung adenocarcinoma

Describes a project that uses

Uses Software

• PhysiCell
• MCELL
• Chaste

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