Modelling transcriptional feedback loops: the role of Gro/TLE1 in Hes1 oscillations

DOI10.1098/RSTA.2006.1761MaRDI QIDQ5301874zbMATH OpenOpenAlexWikidataFDO

Authors Samuel Bernard, Branka Čajavec, Laurent Pujo-Menjouet, M. C. Mackey, Hanspeter Herzel

Publication date 20 January 2009

Published in Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1098/rsta.2006.1761

zbMATH Keywords

Gro/TLE1Hes-1Hill coefficienttranscriptional repression loopturnaround duration

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

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• Mathematical analysis of a biochemical oscillator with delay
• Stability and bifurcations in scalar differential equations with a general distributed delay
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• Stochastic models of gene expression with delayed degradation
• The role of time delay in adaptive cellular negative feedback systems
• Intracellular delay limits cyclic changes in gene expression
• Stochastic delay differential equations for genetic regulatory networks
• Oscillations of Hes7 caused by negative autoregulation and ubiquitination

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