Stability analysis of the family of tumour angiogenesis models with distributed time delays

DOI10.1016/J.CNSNS.2015.08.002MaRDI QIDQ2199481zbMATH OpenOpenAlexWikidataFDO

Authors Marek Bodnar, Monika J. Piotrowska

Publication date 11 September 2020

Published in Communications in Nonlinear Science and Numerical Simulation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1502.07862

zbMATH Keywords

angiogenesisdistributed delayHopf bifurcationstability analysisdelay differential equations

Mathematics Subject Classification ID

Medical applications (general) (92C50) Systems biology, networks (92C42) Stability theory of functional-differential equations (34K20) Bifurcation theory of functional-differential equations (34K18)

Abstract: In the presented paper a family of angiogenesis models, that is a generalisation of Hahnfeldt et al. model is proposed. Considered family of models is a system of two differential equations with distributed time delays. The global existence and the uniqueness of the solutions are proved. Moreover, the stability of the unique positive steady state is examined in the case when delay distributions are Erlang or piecewise linear distributions. Theorems guaranteeing the existence of stability switches and occurrence of the Hopf bifurcation are proved. Theoretical results are illustrated by numerical analysis performed for parameters estimated by Hahnfeldt et al. (Cancer Res., 1999).

Recommendations

• Angiogenesis model with Erlang distributed delays
• Stability of Hahnfeldt angiogenesis models with time lags
• Analysis of the Hopf bifurcation for the family of angiogenesis models. II: The case of two nonzero unequal delays
• Model of tumour angiogenesis -- analysis of stability with respect to delays
• Analysis of the Hopf bifurcation for the family of angiogenesis models

Cites work

• scientific article; zbMATH DE number 430390 (Why is no real title available?)
• scientific article; zbMATH DE number 4170706 (Why is no real title available?)
• scientific article; zbMATH DE number 3973384 (Why is no real title available?)
• scientific article; zbMATH DE number 484710 (Why is no real title available?)
• scientific article; zbMATH DE number 1093004 (Why is no real title available?)
• scientific article; zbMATH DE number 1820648 (Why is no real title available?)
• scientific article; zbMATH DE number 2115876 (Why is no real title available?)
• A continuum mathematical model of the developing murine retinal vasculature
• A family of models of angiogenesis and anti-angiogenesis anti-cancer therapy
• A hybrid discrete-continuum mathematical model of pattern prediction in the developing retinal vasculature
• A simple model of carcinogenic mutations with time delay and diffusion
• Analysis of biochemical reactions models with delays
• Analysis of the Hopf bifurcation for the family of angiogenesis models
• Analysis of the Hopf bifurcation for the family of angiogenesis models. II: The case of two nonzero unequal delays
• AntiAngiogenic Therapy in Cancer Treatment as an Optimal Control Problem
• Applied Delay Differential Equations
• Approximating the Stability Region for a Differential Equation with a Distributed Delay
• BIOLOGICAL DELAY SYSTEMS AND THE MIKHAILOV CRITERION OF STABILITY
• Comparison of six models of antiangiogenic therapy
• Continuous and discrete mathematical models of tumor-induced angiogenesis
• Delay-induced oscillatory dynamics of tumour-immune system interaction
• Functional differential equations with infinite delay
• Global stability of SIR epidemic models with a wide class of nonlinear incidence rates and distributed delays
• Hopf bifurcation in a solid avascular tumour growth model with two discrete delays
• Influence of time delays on the Hahnfeldt et al. angiogenesis model dynamics
• Interaction of maturation delay and nonlinear birth in population and epidemic models
• Introduction to functional differential equations
• Local and global stability for Lotka-Volterra systems with distributed delays and instantaneous negative feedbacks
• Long Period Oscillations in aG₀Model of Hematopoietic Stem Cells
• Mathematical modelling of flow through vascular networks: implications for tumour-induced angiogenesis and chemotherapy strategies
• Mathematical modelling of immune reaction against gliomas: sensitivity analysis and influence of delays
• Model of tumour angiogenesis -- analysis of stability with respect to delays
• Modeling immunotherapy of the tumor -- immune interaction
• Modelling transcriptional feedback loops: the role of Gro/TLE1 in Hes1 oscillations
• New approach to modeling of antiangiogenic treatment on the basis of Hahnfeldt et al. model
• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• Numerical modelling in biosciences using delay differential equations
• On optimal delivery of combination therapy for tumors
• Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis
• Optimal scheduling of radiotherapy and angiogenic inhibitors
• Simple ODE models of tumor growth and anti-angiogenic or radiation treatment
• Stability conditions for a class of delay differential equations in single species population dynamics
• Stability implications of delay distribution for first-order and second-order systems
• Stability of delay induced oscillations in gene expression of Hes1 protein model
• Stochastic models of gene expression with delayed degradation
• Sufficient conditions for stability of linear differential equations with distributed delay
• THREE TYPES OF SIMPLE DDE'S DESCRIBING TUMOR GROWTH
• The effect of time delays on the dynamics of avascular tumor growth
• The response to antiangiogenic anticancer drugs that inhibit endothelial cell proliferation
• Time delays in proliferation process for solid avascular tumour
• Time delays in regulatory apoptosis for solid avascular tumour
• Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)

Cited in

(20)

• The stability analysis of tumor-immune responses to chemotherapy system driven by Gaussian colored noises
• Influence of distributed delays on the dynamics of a generalized immune system cancerous cells interactions model
• Generalized exponential input-to-state stability of nonlinear systems with time delay
• Influence of time delays on the Hahnfeldt et al. angiogenesis model dynamics
• A deterministic and stochastic model for the system dynamics of tumor-immune responses to chemotherapy
• Stability of Hahnfeldt angiogenesis models with time lags
• On the analysis of a mathematical model of CAR-T cell therapy for glioblastoma: insights from a mathematical model
• A Delayed Dynamical Model Describing the Effect of Tumor-Induced Vascular Endothelial Growth Factor on Angiogenesis: Backward Bifurcations and Global Dynamics
• Control strategies for a tumor-immune system with impulsive drug delivery under a random environment
• scientific article; zbMATH DE number 5666705 (Why is no real title available?)
• Angiogenesis model with Erlang distributed delays
• Periodic solutions of angiogenesis models with time lags
• Stability and bifurcation analysis for the Kaldor-Kalecki model with a discrete delay and a distributed delay
• Noise and delay enhanced stability in tumor-immune responses to chemotherapy system
• Nonoscillation of higher order mixed differential equations with distributed delays
• Analysis of the Hopf bifurcation for the family of angiogenesis models
• Analysis of the Hopf bifurcation for the family of angiogenesis models. II: The case of two nonzero unequal delays
• Effects of delay in a biological environment subject to tumor dynamics
• Angiogenesis model with carrying capacity depending on vessel density
• Model of tumour angiogenesis -- analysis of stability with respect to delays

This page was built for publication: Stability analysis of the family of tumour angiogenesis models with distributed time delays

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2199481)