Stability analysis of the family of tumour angiogenesis models with distributed time delays
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Publication:2199481
DOI10.1016/J.CNSNS.2015.08.002zbMATH Open1467.92087arXiv1502.07862OpenAlexW1569715683WikidataQ112197545 ScholiaQ112197545MaRDI QIDQ2199481FDOQ2199481
Authors: Marek Bodnar, Monika J. Piotrowska 
Publication date: 11 September 2020
Published in: Communications in Nonlinear Science and Numerical Simulation (Search for Journal in Brave)
Abstract: In the presented paper a family of angiogenesis models, that is a generalisation of Hahnfeldt et al. model is proposed. Considered family of models is a system of two differential equations with distributed time delays. The global existence and the uniqueness of the solutions are proved. Moreover, the stability of the unique positive steady state is examined in the case when delay distributions are Erlang or piecewise linear distributions. Theorems guaranteeing the existence of stability switches and occurrence of the Hopf bifurcation are proved. Theoretical results are illustrated by numerical analysis performed for parameters estimated by Hahnfeldt et al. (Cancer Res., 1999).
Full work available at URL: https://arxiv.org/abs/1502.07862
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Medical applications (general) (92C50) Systems biology, networks (92C42) Stability theory of functional-differential equations (34K20) Bifurcation theory of functional-differential equations (34K18)
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