A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data

DOI10.1016/S0025-5564(03)00040-3zbMath1024.92012WikidataQ30788555 ScholiaQ30788555MaRDI QIDQ1810722

Mark P. Little, E. G. Wright

Publication date: 9 June 2003

Published in: Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

carcinogenesisionizing radiationKolmogorov backward equationscolon cancerKolmogorov forward equationsgenomic instabilitystochastic quasi-mechanistic modelsJapanese atomic bomb survivors

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70)

Related Items (15)

Spatial stochastic models for cancer initiation and progression ⋮ Loss- and gain-of-function mutations in cancer: mass-action, spatial and hierarchical models ⋮ Evolutionary dynamics of invasion and escape ⋮ A two-phase Poisson process model and its application to analysis of cancer mortality among A-bomb survivors ⋮ New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms ⋮ Genetic instability and clonal expansion ⋮ Genetic instability and the quasispecies model ⋮ Dynamics of metastasis suppressor gene inactivation ⋮ Stochastic dynamics of metastasis formation ⋮ A multi-compartment cell repopulation model allowing for inter-compartmental migration following radiation exposure, applied to leukaemia ⋮ STOCHASTIC MODELING OF LOSS- AND GAIN-OF-FUNCTION MUTATIONS IN CANCER ⋮ The fixed-size Luria-Delbrück model with a nonzero death rate ⋮ A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data ⋮ Risk of lung cancer due to external environmental factor and epidemiological data analysis ⋮ The Case‐Only Odds Ratio as a Causal Parameter

Uses Software

• NAG
• nag
• pyuvdata
• bootlib

Cites Work

• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors
• Are Two Mutations Sufficient to Cause Cancer? Some Generalizations of the Two-Mutation Model of Carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the Multistage Model of Armitage and Doll
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