Analytical solution and exposure analysis of a pharmacokinetic model with simultaneous elimination pathways and endogenous production: the case of multiple dosing administration

DOI10.1007/S11538-019-00651-8zbMath1426.92031OpenAlexW2968015489WikidataQ92669949 ScholiaQ92669949MaRDI QIDQ2334387

Xiaotian Wu, Fahima Nekka, Jun Li

Publication date: 7 November 2019

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-019-00651-8

zbMATH Keywords

pharmacokinetic modelendogenous productionarea under the curve at steady stateaverage concentration at steady statesimultaneous first-order and Michaelis-Menten elimination

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Related Items (4)

An analytical approach of one-compartmental pharmacokinetic models with sigmoidal Hill elimination ⋮ Statistical analysis of two-compartment pharmacokinetic models with drug non-adherence ⋮ Steady-state drug exposure of repeated IV bolus administration for a one compartment pharmacokinetic model with sigmoidal Hill elimination ⋮ What can mathematics do for drug development?

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