Topics in mathematical pharmacology

DOI10.1007/S10884-015-9468-4MaRDI QIDQ330557zbMATH OpenOpenAlexWikidataFDO

Authors Piet H. van der Graaf, Neil Benson, Lambertus A. Peletier

Publication date 26 October 2016

Published in Journal of Dynamics and Differential Equations (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/s10884-015-9468-4

zbMATH Keywords

TMDDdrug-dispositionmodular systemsRTK'ssignalling

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

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Cites work

• A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback
• Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency

Cited in

(22)

• Optimization of additive chemotherapy combinations for an in vitro cell cycle model with constant drug exposures
• Selecting optimal drug-intervention in a pathway involving receptor tyrosine kinases (RTKs)
• Analytical solution and exposure analysis of a pharmacokinetic model with simultaneous elimination pathways and endogenous production: the case of multiple dosing administration
• An invitation to pharmacostatics
• Slow invariant manifolds of singularly perturbed systems via physics-informed machine learning
• scientific article; zbMATH DE number 4060923 (Why is no real title available?)
• Challenges in pharmacology modelling
• A stochastic reaction scheme for drug/metabolite interaction
• Modeling drug-protein dynamics
• scientific article; zbMATH DE number 3882241 (Why is no real title available?)
• Model of complex chiral drug metabolic systems and numerical simulation of the remaining chirality toward analysis of dynamical pharmacological activity
• Mathematical concepts in pharmacokinetics and pharmacodynamics with application to tumor growth
• Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
• Stability analysis of drug dynamics model: a mathematical approach
• Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis
• Steady-state drug exposure of repeated IV bolus administration for a one compartment pharmacokinetic model with sigmoidal Hill elimination
• Geometric singular perturbation analysis of a dynamical target mediated drug disposition model
• Analysis of a complex physiology-directed model for inhibition of platelet aggregation by clopidogrel
• Compounds, drugs and mathematical image processing
• A model for the interaction of two chemicals
• Asymptotic analysis of a TMDD model: when a reaction contributes to the destruction of its product
• Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes

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