A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD\(8^+\) T cell immune response

DOI10.1016/J.JTBI.2022.111028zbMath1483.92050arXiv2107.05569OpenAlexW3180731645WikidataQ113869615 ScholiaQ113869615MaRDI QIDQ2670180

Yanyan Li

Publication date: 10 March 2022

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/2107.05569

zbMATH Keywords

numerical simulationsindividual-based modelsantigen presentationintra-tumour heterogeneitytumour-immune cell interactions

Mathematics Subject Classification ID

Medical applications (general) (92C50) Cell movement (chemotaxis, etc.) (92C17) Pathology, pathophysiology (92C32)

Related Items (3)

Computational modeling to determine the effect of phenotypic heterogeneity in tumors on the collective tumor-immune interactions ⋮ Modeling tumour heterogeneity of PD-L1 expression in tumour progression and adaptive therapy ⋮ A hybrid discrete-continuum modelling approach to explore the impact of T-cell infiltration on anti-tumour immune response

Uses Software

• PhysiCell
• CompuCell3D

Cites Work

• Evolution of genetic instability in heterogeneous tumors
• Recognition and learning in a mathematical model for immune response against cancer
• Numerical simulations for tumor and cellular immune system interactions in lung cancer treatment
• Evolutionary dynamics of phenotype-structured populations: from individual-level mechanisms to population-level consequences
• Spatial tumor-immune modeling
• Modeling immunotherapy of the tumor -- immune interaction
• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• Individual-based approaches to birth and death in avascular tumors
• Modelling the immune response to cancer: an individual-based approach accounting for the difference in movement between inactive and activated T cells
• A cellular automata model of tumor-immune system interactions
• A size and space structured model describing interactions of tumor cells with immune cells reveals cancer persistent equilibrium states in tumorigenesis
• Mathematical modelling of the spatio-temporal response of cytotoxic T-lymphocytes to a solid tumour

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