A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach

From MaRDI portal
Revision as of 15:31, 3 February 2024 by Import240129110113 (talk | contribs) (Created automatically from import240129110113)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Publication:2767515


DOI10.1080/10273660108833067zbMath0985.92023MaRDI QIDQ2767515

L. G. de Pillis, A. E. Radunskaya

Publication date: 30 May 2002

Published in: Journal of Theoretical Medicine (Search for Journal in Brave)

Full work available at URL: https://eudml.org/doc/226953


49N90: Applications of optimal control and differential games

92C50: Medical applications (general)


Related Items

On a multiobjective optimal control of a tumor growth model with immune response and drug therapies, Stability of a Mathematical Model with Piecewise Constant Arguments for Tumor-Immune Interaction Under Drug Therapy, Can the original equations of a dynamical system be retrieved from observational time series?, Efficiency of cancer treatments: in silico experiments, Effects of delayed immune-activation in the dynamics of tumor-immune interactions, Optimal control for a mathematical model for chemotherapy with pharmacometrics, A NEW MATHEMATICAL MODELING AND SUB-OPTIMAL CHEMOTHERAPY OF CANCER, Optimal bounded controls problem for bilinear systems, Analysis of the dynamics of a tumor-immune system with chemotherapy and immunotherapy and quadratic optimal control, Personalized drug administration for cancer treatment using model reference adaptive control, Effects of the obesity on optimal control schedules of chemotherapy on a cancerous tumor, Mathematical modelling and analysis of the tumor treatment regimens with pulsed immunotherapy and chemotherapy, The tumor growth paradox and immune system-mediated selection for cancer stem cells, Multi-input optimal control problems for combined tumor anti-angiogenic and radiotherapy treatments, Chaos in a tumor growth model with delayed responses of the immune system, Modelling lymphoma therapy and outcome, Stability and bifurcation analysis of a mathematical model for tumor-immune interaction with piecewise constant arguments of delay, Cost-effectiveness analysis of optimal strategy for tumor treatment, Dynamic analysis of an antitumor model and investigation of the therapeutic effects for different treatment regimens, Computational modeling of tumor response to vascular-targeting therapies. I: Validation, The chaos and optimal control of cancer model with complete unknown parameters, Optimal control for selected cancer chemotherapy ODE models: a view on the potential of optimal schedules and choice of objective function, Optimal response to chemotherapy for a mathematical model of tumor-immune dynamics, Mathematical analysis of a tumour-immune interaction model: a moving boundary problem, A cancer model for the angiogenic switch, On probabilistic certification of combined cancer therapies using strongly uncertain models, Identifying and characterising the impact of excitability in a mathematical model of tumour-immune interactions, Chaos and optimal control of cancer self-remission and tumor system steady states, A two-compartment model interacting with dynamic drugs, On optimal delivery of combination therapy for tumors, Two-compartment model interacting with proliferating regulatory factor, The dynamics of an optimally controlled tumor model: A case study, Mixed immunotherapy and chemotherapy of tumors: feedback design and model updating schemes, Combination therapies and intra-tumoral competition: insights from mathematical modeling, A time delay model of tumour-immune system interactions: global dynamics, parameter estimation, sensitivity analysis, Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment, Global stability analysis and optimal control therapy of blood cell production process (hematopoiesis) in acute myeloid leukemia, Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine, A two-phenotype model of immune evasion by cancer cells, Bounding the dynamics of a chaotic-cancer mathematical model, Dynamical behaviour of a tumor-immune system with chemotherapy and optimal control, The combined effects of optimal control in cancer remission, Optimal control for a mathematical model of glioma treatment with oncolytic therapy and TNF-\(\alpha \) inhibitors, Periodic and chaotic dynamics in a map-based model of tumor-immune interaction, Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis, Assessing the effects of estrogen on the dynamics of breast cancer, Analysis of the effectiveness of the treatment of solid tumors in two cases of drug administration, Predictive drug dosage control through a Fokker-Planck observer, Extinction and persistence of a tumor-immune model with white noise and pulsed comprehensive therapy, Dynamic analysis of a tumor-immune system under Allee effect, A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia, Optimal control of tumour-immune model with time-delay and immuno-chemotherapy, Spatial avascular growth of tumor in a homogeneous environment, On the role of the objective in the optimization of compartmental models for biomedical therapies, On the role of pharmacometrics in mathematical models for cancer treatments, Combined therapy for treating solid tumors with chemotherapy and angiogenic inhibitors, Application of control theory in a delayed-infection and immune-evading oncolytic virotherapy, Mathematical modeling and dynamic analysis of anti-tumor immune response, Insights into the dynamics of blood conveying gold nanoparticles on a curved surface when suction, thermal radiation, and Lorentz force are significant: the case of non-Newtonian Williamson fluid, Modeling the virus-induced tumor-specific immune response with delay in tumor virotherapy, Combination of virotherapy and chemotherapy with optimal control for combating cancer, A multi-drug pharmacokinectic optimal control approach in cancer chemotherapy, Mathematical models of leukaemia and its treatment: a review, Effects of delay in a biological environment subject to tumor dynamics, Bifurcation, multistability in the dynamics of tumor growth and electronic simulations by the use of Pspice, Is the Allee effect relevant in cancer evolution and therapy?, Investigating of an immune system-cancer mathematical model with Mittag-Leffler kernel, Role of immunotherapy in tumor-immune interaction: perspectives from fractional-order modelling and sensitivity analysis, Optimal control problem for a general reaction-diffusion tumor-immune interaction system of mixed immunotherapy and chemotherapy, Optimal control with isoperimetric constraint for chemotherapy of tumors, Adaptive backstepping controller design for MIMO cancer immunotherapy using Laguerre polynomials, Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations, A cellular automata model of tumor-immune system interactions, An immune system-tumour interactions model with discrete time delay: model analysis and validation, New observations on optimal cancer treatments for a fractional tumor growth model with and without singular kernel, Influence of distributed delays on the dynamics of a generalized immune system cancerous cells interactions model, Global dynamics of a breast cancer competition model, Optimization of interleukin-21 immunotherapeutic strategies, Cancer immunotherapy, mathematical modeling and optimal control, Optimal CAR T-cell immunotherapy strategies for a leukemia treatment model, Optimal control problem for a general reaction-diffusion tumor-immune system with chemotherapy, Global solvability and optimal control to a haptotaxis cancer invasion model with two cancer cell species, Robust domain of attraction estimation for a tumor growth model, Delay differential model for tumour-immune response with chemoimmunotherapy and optimal control, Targeting the quiescent cells in cancer chemotherapy treatment: is it enough?, A mathematical model for the effect of obesity on cancer growth and on the immune system response, Modelling of tumor cells regression in response to chemotherapeutic treatment, Dynamics of tumor growth: chemotherapy and integrative oncology, Numerical optimal control of a size-structured PDE model for metastatic cancer treatment, Dynamics of breast cancer under different rates of chemoradiotherapy, Mixed therapy in cancer treatment for personalized drug administration using model reference adaptive control, A dynamic simulation of the immune system response to inhibit and eliminate abnormal cells, Iterative method for estimating the robust domains of attraction of non-linear systems: application to cancer chemotherapy model with parametric uncertainties, Interactions between the immune system and cancer: A brief review of non-spatial mathematical models, Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls, Sliding mode control in a mathematical model to chemoimmunotherapy: the occurrence of typical singularities, Phase-specific cancer-immune model considering acquired resistance to therapeutic agents, Cancer cell eradication in a 6D metastatic tumor model with time delay, Unnamed Item, Optimal Control of Cancer Treatments: Mathematical Models for the Tumor Microenvironment, Dynamical behaviour of a tumour-immune model focusing on the dosage of targeted chemotherapeutic drug, AN ADAPTIVE PHARMACOKINETIC OPTIMAL CONTROL APPROACH IN CHEMOTHERAPY FOR HETEROGENEOUS TUMOR, THE EFFECT OF LENVATINIB AND PEMBROLIZUMAB ON THYROID CANCER REFRACTORY TO IODINE 131I SIMULATED BY MATHEMATICAL MODELING, Dynamics of a Mathematical Model of Cancer and Immunoediting Scenarios Under the Variation of the Immune Cell Activation Rate, Bifurcation and chaos analysis of tumor growth, Developing and studying the dynamical behavior of a nonlinear mathematical model for cancers with tumor by considering immune system role, Bifurcation Analysis in a Cancer Growth Model, Fractional order model of immune cells influenced by cancer cells, The effect of finite duration inputs on the dynamics of a system: Proposing a new approach for cancer treatment, Constrained bilinear control problem: Application to a cancer chemotherapy model, Optimal control homotopy perturbation method for cancer model, Robust feedback design for combined therapy of cancer, Optimal chemotherapy in cancer treatment: state dependent Riccati equation control and extended Kalman filter, Unnamed Item, Bifurcation analysis of the cancer virotherapy system with time delay and diffusion, A nonlinear transport-diffusion model for the interactions between immune system cells and HPV-infected cells, Learning-based sensitivity analysis and feedback design for drug delivery of mixed therapy of cancer in the presence of high model uncertainties