How the formation of amyloid plaques and neurofibrillary tangles may be related: a mathematical modelling study

DOI10.1098/rspa.2017.0777zbMath1402.92099OpenAlexW2785609893WikidataQ53396189 ScholiaQ53396189MaRDI QIDQ4559556

Andrey V. Kuznetsov, Ivan A. Kuznetsov

Publication date: 4 December 2018

Published in: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1098/rspa.2017.0777

zbMATH Keywords

mathematical modellingAlzheimer's diseaseneuronaxontau proteinamyloid precursor protein

Mathematics Subject Classification ID

Neural biology (92C20) Medical applications (general) (92C50)

Related Items (3)

Bidirectional, unlike unidirectional transport, allows transporting axonal cargos against their concentration gradient ⋮ A mathematical model demonstrating the role of interstitial fluid flow on the clearance and accumulation of amyloid \(\beta\) in the brain ⋮ Simulating the effect of formation of amyloid plaques on aggregation of tau protein

Cites Work

• On the validity of the steady state assumption of enzyme kinetics
• Optimally weightedL²distance for functional data
• A comparison between the diffusion–reaction and slow axonal transport models for predicting tau distribution along an axon
• Simulating tubulin-associated unit transport in an axon: using bootstrapping for estimating confidence intervals of best-fit parameter values obtained from indirect experimental data

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