Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics

DOI10.1081/BIP-120019267zbMath1180.62182WikidataQ52017271 ScholiaQ52017271MaRDI QIDQ4803377

France Mentré, Sylvie Retout

Publication date: 2 April 2003

Published in: Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Statistical aspects of information-theoretic topics (62B10)

Related Items (14)

Evaluation of the Fisher information matrix in nonlinear mixed effect models using adaptive Gaussian quadrature ⋮ Efficient Algorithms for Optimal Designs with Correlated Observations in Pharmacokinetics and Dose-Finding Studies ⋮ Optimal design for population pk/pd models ⋮ Design optimality for models defined by a system of ordinary differential equations ⋮ Simulation-based fully Bayesian experimental design for mixed effects models ⋮ Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics ⋮ Optimum Designs for Non-Linear Mixed Effects Models in the Presence of Covariates ⋮ PkStaMp Library for Constructing Optimal Population Designs for PK/PD Studies ⋮ Optimal cross-over designs for nonlinear mixed models using a first-order expansion ⋮ On the Choice of a Prior for Bayesian D-Optimal Designs for the Logistic Regression Model with a Single Predictor ⋮ Approximate testing in two-stage nonlinear mixed models ⋮ Design Optimization in Nonlinear Mixed Effects Models Using Cost Functions: Application to a Joint Model of Infliximab and Methotrexate Pharmacokinetics ⋮ A geometric characterization of \(c\)-optimal designs for heteroscedastic regression ⋮ Approximate Small-Sample Tests of Fixed Effects in Nonlinear Mixed Models

Uses Software

• SAS

Cites Work

• Robust experiment design via stochastic approximation
• Design of cross-over trials for pharmacokinetic studies
• A simulated pseudo-maximum likelihood estimator for nonlinear mixed models.
• Laplace's approximation for nonlinear mixed models
• Optimal design in random-effects regression models
• MULTIPLE-OBJECTIVE DESIGNS IN A DOSE-RESPONSE EXPERIMENT
• Population Pharmacokinetic/Pharmacodynamic Methodology and Applications: A Bibliography

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