Discrete and continuum phenotype-structured models for the evolution of cancer cell populations under chemotherapy

DOI10.1051/mmnp/2019027zbMath1467.92101OpenAlexW3011889833MaRDI QIDQ5001268

Anna Marciniak-Czochra, Tommaso Lorenzi, Rebecca E. A. Stace, Thomas Stiehl, Mark A. J. Chaplain

Publication date: 19 July 2021

Published in: Mathematical Modelling of Natural Phenomena (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1051/mmnp/2019027

zbMATH Keywords

chemotherapynonlocal parabolic equationsindividual-based modelscancer cell populationsepigenetic drugs

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Medical applications (general) (92C50) Cell biology (92C37) Parabolic equations and parabolic systems (35K99) Pathology, pathophysiology (92C32)

Related Items (10)

Phenotype-structured model of intra-clonal heterogeneity and drug resistance in multiple myeloma ⋮ A mathematical dissection of the adaptation of cell populations to fluctuating oxygen levels ⋮ Evolutionary dynamics in vascularised tumours under chemotherapy: mathematical modelling, asymptotic analysis and numerical simulations ⋮ Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia ⋮ Evolutionary dynamics in an SI epidemic model with phenotype-structured susceptible compartment ⋮ Modeling the Emergence of Phenotypic Heterogeneity in Vascularized Tumors ⋮ Evolution of cancer cell populations under cytotoxic therapy and treatment optimisation: insight from a phenotype-structured model ⋮ Discrete and Continuum Models for the Evolutionary and Spatial Dynamics of Cancer: A Very Short Introduction Through Two Case Studies ⋮ Spatio-temporal modelling of phenotypic heterogeneity in tumour tissues and its impact on radiotherapy treatment ⋮ Mathematical model for the estrogen paradox in breast cancer treatment

Uses Software

• DLMF

Cites Work

• Unnamed Item
• A mathematical model for the dynamics of cancer hepatocytes under therapeutic actions
• Effects of an advection term in nonlocal Lotka-Volterra equations
• Evolutionary dynamics of phenotype-structured populations: from individual-level mechanisms to population-level consequences
• Dissecting the dynamics of epigenetic changes in phenotype-structured populations exposed to fluctuating environments
• Continuous and discrete mathematical models of tumor-induced angiogenesis
• The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
• Mathematical oncology
• Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy
• Modeling the dynamics of heterogeneity of solid tumors in response to chemotherapy
• What does not kill a tumour may make it stronger: \textit{in silico} insights into chemotherapeutic drug resistance
• Modeling the chemotherapy-induced selection of drug-resistant traits during tumor growth
• Dynamic heterogeneous spatio-temporal pattern formation in host-parasitoid systems with synchronised generations
• Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors
• Examining the role of individual movement in promoting coexistence in a spatially explicit prisoner's dilemma
• A mathematical framework for modelling the metastatic spread of cancer
• Combination of direct methods and homotopy in numerical optimal control: application to the optimization of chemotherapy in cancer
• Unifying evolutionary dynamics: from individual stochastic processes to macroscopic models
• Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies
• Hybrid Model of Erythropoiesis and Leukemia Treatment with Cytosine Arabinoside
• Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients
• Dynamical Patterns of Coexisting Strategies in a Hybrid Discrete-continuum Spatial Evolutionary Game Model
• Evolution of cancer cell populations under cytotoxic therapy and treatment optimisation: insight from a phenotype-structured model

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