Phenotypic heterogeneity in a model of tumour growth: existence of solutions and incompressible limit

DOI10.1080/03605302.2023.2191265zbMath1518.35159arXiv2204.05590OpenAlexW4376106974MaRDI QIDQ6116612

Noemi David

Publication date: 18 July 2023

Published in: Communications in Partial Differential Equations (Search for Journal in Brave)

Abstract: We consider a (degenerate) cross-diffusion model of tumor growth structured by phenotypic trait. We prove the existence of weak solutions and the incompressible limit as the pressure becomes stiff extending methods recently introduced in the context of two-species cross-diffusion systems. In the stiff-pressure limit, the compressible model generates a free boundary problem of Hele-Shaw type. Moreover, we prove a new L4-bound on the pressure gradient.

Full work available at URL: https://arxiv.org/abs/2204.05590

zbMATH Keywords

porous mediumtumour growthfree boundaryincompressible limitstructured modelAronson-Bénilan estimate

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Degenerate parabolic equations (35K65) A priori estimates in context of PDEs (35B45) Existence, uniqueness, and regularity theory for compressible fluids and gas dynamics (76N10) Integro-partial differential equations (35R09) Quasilinear parabolic equations (35K59)

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