A stem cell model for carcinogenesis

DOI10.1016/0025-5564(94)90053-1MaRDI QIDQ1325042zbMATH OpenOpenAlexWikidataFDO

Authors Annette Kopp-Schneider, Christopher J. Portier

Publication date 7 July 1994

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(94)90053-1

zbMATH Keywords

Kolmogorov equationsclonal expansioncumulative distributionreflecting barrierintermediate cellsmalignant tumorsnumber of detectable intermediate cell clonespapilloma formationtwo-stage model of carcinogenesis

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of branching processes (60J85)

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Cites work

• scientific article; zbMATH DE number 3174818 (Why is no real title available?)
• scientific article; zbMATH DE number 3249395 (Why is no real title available?)
• A stochastic Gompertz birth-death process
• Analyzing Repeated Measures on Generalized Linear Models via the Bootstrap
• Birth-and-death processes, and the theory of carcinogenesis
• Birth-death processes with piecewise constant rates
• The application of a multistage model that incorporates DNA damage and repair to the analysis of initiation/promotion experiments
• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors

Cited in

(8)

• A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
• Two stage model for carcinogenesis: Number and size distributions of premalignant clones in longitudinal studies
• Calculating tumor incidence rates in stochastic models of carcinogenesis
• An exact representation for the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth
• Some mixed models of carcinogenesis
• A stochastic model of mutant growth
• Incorporating observability thresholds of tumors into the two-stage carcinogenesis model
• An application of a two-level non-Gaussian state-space model in the analysis of longitudinal papilloma count data

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