Diversity against adversity: how adaptive immune system evolves potent antibodies

DOI10.1007/S10955-011-0241-8MaRDI QIDQ639322zbMATH OpenOpenAlexFDO

Authors Muyoung Heo, Konstantin B. Zeldovich, Eugene I. Shakhnovich

Publication date 20 September 2011

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s10955-011-0241-8

zbMATH Keywords

germinal centersimmune responseB cellsDarwinian evolutionadaptive immunitysomatic hypermutationsequence diversity

Mathematics Subject Classification ID

Problems related to evolution (92D15) Protein sequences, DNA sequences (92D20) Interacting particle systems in time-dependent statistical mechanics (82C22) Cell biology (92C37)

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• COMPLEX BIOLOGICAL IMMUNE SYSTEM THROUGH THE EYES OF DUAL-PHASE EVOLUTION
• scientific article; zbMATH DE number 3867103 (Why is no real title available?)
• Modeling immunodominance in the B-cell response to viral infection
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• The benefits of diversity: heterogenous DC populations allow for both immunity and tolerance

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