Modeling and optimization of populations subject to time-dependent mutation.

DOI10.1073/PNAS.92.18.8219MaRDI QIDQ4856915zbMATH OpenOpenAlexWikidataFDO

Authors Alan S. Perelson, Thomas B. Kepler

Publication date 5 March 1996

Published in Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL https://europepmc.org/articles/pmc41128

zbMATH Keywords

affinity maturationantibody affinity maturationdeterministic threshold modelenvironmental conditionshybrid modelMonte Carlo simulationmutation rateoptimal controloptimal mutation schedulesomatic hypermutationstochastic model

Mathematics Subject Classification ID

Problems related to evolution (92D15)

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Cited in

(13)

• Evolution on a smooth landscape
• Random walks on binary strings applied to the somatic hypermutation of B-cells
• A numerical approach to determine mutant invasion fitness and evolutionary singular strategies
• The optimal burst of mutation to create a phenotype
• Density dependent replicator-mutator models in directed evolution
• Aging transition under discrete time-dependent coupling: restoring rhythmicity from aging
• Adaptive force produced by stress-induced regulation of random variation intensity
• Front propagation dynamics with exponentially-distributed hopping
• A quantitative study of the dynamics of adaptive mutation appearance
• Waiting times to appearance and dominance of advantageous mutants: Estimation based on the likelihood
• A coupled evolutionary model of the viral virulence in an SIS community
• Diversity against adversity: how adaptive immune system evolves potent antibodies
• A branching stochastic evolutionary model of the B-cell repertoire

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