Density dependent replicator-mutator models in directed evolution

DOI10.3934/DCDSB.2019224zbMATH Open1445.35194arXiv1901.07848OpenAlexW2971766006MaRDI QIDQ1987150FDOQ1987150

Authors: Matthieu Alfaro, Mario Veruete 

Publication date: 9 April 2020

Published in: Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Abstract: We analyze a replicator-mutator model arising in the context of directed evolution [23], where the selection term is modulated over time by the mean-fitness. We combine a Cumulant Generating Function approach [13] and a spatio-temporal rescaling related to the Avron-Herbst formula [1] to give of a complete picture of the Cauchy problem. Besides its well-posedness, we provide an implicit/explicit expression of the solution, and analyze its large time behaviour. As a by product, we also solve a replicator-mutator model where the mutation coefficient is socially determined, in the sense that it is modulated by the mean-fitness. The latter model reveals concentration or anti diffusion/diffusion phenomena.

Full work available at URL: https://arxiv.org/abs/1901.07848

Recommendations

• Mutation rate evolution in replicator dynamics
• Replicator - Mutator Evolutionary Dynamics
• Density behavior of spatial birth-and-death stochastic evolution of mutating genotypes under selection rates
• Evolutionary branching via replicator-mutator equations
• Evolutionary dynamics of a polymorphic self-replicator population with a finite population size and hyper mutation rate
• Selection-mutation dynamics with spatial dependence
• Mutation rates and equilibrium selection under stochastic evolutionary dynamics
• Mutation-selection models in population genetics and evolutionary game theory
• Dynamics in stochastic evolutionary models
• Modeling and optimization of populations subject to time-dependent mutation.

zbMATH Keywords

long time behaviourcumulant generating functionnonlocal PDEreplicator-mutator dynamicsGaussian solutionsintegro-differential PDE

Mathematics Subject Classification ID

Asymptotic behavior of solutions to PDEs (35B40) Positive solutions to PDEs (35B09) Initial value problems for second-order parabolic equations (35K15) Integro-partial differential equations (35R09) General biology and biomathematics (92B05)

Cites Work

• Title not available (Why is that?)
• Evolutionarily stable strategies and game dynamics
• Perturbations of positive semigroups and applications to population genetics
• A stochastic model concerning the maintenance of genetic variability in quantitative characters.
• Mutation in autocatalytic reaction networks. An analysis based on perturbation theory
• Evolution of universal grammar
• Mutation-selection balance and continuum-of-alleles models
• Explicit solutions for replicator-mutator equations: extinction versus acceleration
• Equilibrium Distributions of Continuous Polygenic Traits
• Stability by mutation in evolutionary games
• Stable Polymorphisms in a Selection Model with Mutation
• Evolutionary branching via replicator-mutator equations
• A simple mathematical model of gradual Darwinian evolution: emergence of a Gaussian trait distribution in adaptation along a fitness gradient
• Universal dynamics for the defocusing logarithmic Schrödinger equation
• On the maintenance of genetic variation: Global analysis of Kimura's continuum-of-alleles model
• Mathematical Properties of a Class of Integro-differential Models from Population Genetics
• Dynamics of fitness distributions in the presence of a phenotypic optimum: an integro-differential approach
• Superexponential growth or decay in the heat equation with a logarithmic nonlinearity
• Natural selection in compartmentalized environment with reshuffling
• Replicator-mutator equations with quadratic fitness

Cited In (7)

• Degeneracy-driven self-structuring dynamics in selective repertoires
• Explicit solutions for replicator-mutator equations: extinction versus acceleration
• Replicator-mutator equations with quadratic fitness
• Replicator - Mutator Evolutionary Dynamics
• Global solutions to an equation for mutation process in bacteria and its preservation of positive supports
• DIFFUSION OF A POPULATION OF INTERACTING REPLICATORS IN SEQUENCE SPACE
• Density behavior of spatial birth-and-death stochastic evolution of mutating genotypes under selection rates

This page was built for publication: Density dependent replicator-mutator models in directed evolution

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1987150)