Multi-type Galton-Watson processes with affinity-dependent selection applied to antibody affinity maturation

DOI10.1007/S11538-018-00548-YMaRDI QIDQ2633576zbMATH OpenOpenAlexWikidataFDO

Authors Irene Balelli, Gilles Wainrib, Vuk Milišić

Publication date 9 May 2019

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1609.00823

zbMATH Keywords

affinity-dependent selectionevolutionary landscapesgerminal center reactionmulti-type Galton-Watson process

Mathematics Subject Classification ID

Applications of branching processes (60J85) Problems related to evolution (92D15)

Abstract: We analyze the interactions between division, mutation and selection in a simplified evolutionary model, assuming that the population observed can be classified into fitness levels. The construction of our mathematical framework is motivated by the modeling of antibody affinity maturation of B-cells in Germinal Centers during an immune response. This is a key process in adaptive immunity leading to the production of high affinity antibodies against a presented antigen. Our aim is to understand how the different biological parameters affect the system's functionality. We identify the existence of an optimal value of the selection rate, able to maximize the number of selected B-cells for a given generation.

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Cites work

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Cited in

(9)

• Random walks on binary strings applied to the somatic hypermutation of B-cells
• Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study
• Understanding memory B cell selection
• Survival analysis of DNA mutation motifs with penalized proportional hazards
• An analysis of B cell selection mechanisms in germinal centers
• A CONCERTED ACTION OF B CELL SELECTION MECHANISMS
• Mathematical modeling of lymphocytes selection in the germinal center
• Diversity against adversity: how adaptive immune system evolves potent antibodies
• A branching stochastic evolutionary model of the B-cell repertoire

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