Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study

DOI10.1016/J.JTBI.2008.08.005MaRDI QIDQ1798191zbMATH OpenOpenAlexWikidataFDO

Authors Gitit Shahaf, Michal Barak, Neta S. Zuckerman, Naamah Swerdlin, M. Gorfine, Ramit Mehr

Publication date 23 October 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2008.08.005

zbMATH Keywords

B lymphocytegerminal center (GC)immunoglobulin (Ig) gene lineage treesmathematical modelsomatic hypermutation (SHM)

Mathematics Subject Classification ID

Cell biology (92C37) Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10)

Recommendations

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Cites work

• A CONCERTED ACTION OF B CELL SELECTION MECHANISMS
• A note on a general definition of the coefficient of determination
• A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation
• scientific article; zbMATH DE number 3251902 (Why is no real title available?)
• Measures of Association for Cross Classifications
• Memory in idiotypic networks due to competition between proliferation and differentiation
• On Randomness in Ordered Sequences
• The type of seeder cells determines the efficiency of germinal center reactions

Cited in

(3)

• Understanding memory B cell selection
• An analysis of B cell selection mechanisms in germinal centers
• Exploration of factors affecting the onset and maturation course of follicular lymphoma through simulations of the germinal center

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