Instability margin analysis for parametrized LTI systems with application to repressilator

DOI10.1016/J.AUTOMATICA.2021.110047MaRDI QIDQ2063808zbMATH OpenOpenAlexFDO

Authors Shinji Hara, Yutaka Hori, Tetsuya Iwasaki

Publication date 3 January 2022

Published in Automatica (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2008.10983

zbMATH Keywords

analysis of systems with uncertaintiesrepressilatorperiodic oscillationinstability marginrobust instability

Mathematics Subject Classification ID

Linear systems in control theory (93C05) Perturbations in control/observation systems (93C73) Robust stability (93D09)

Abstract: This paper is concerned with a robust instability analysis for the single-input-single-output unstable linear time-invariant (LTI) system under dynamic perturbations. The nominal system itself is possibly perturbed by the static gain of the uncertainty, which would be the case when a nonlinear uncertain system is linearized around an equilibrium point. We define the robust instability radius as the smallest $H_{i}nfty$ norm of the stable linear perturbation that stabilizes the nominal system. There are two main theoretical results: one is on a partial characterization of unperturbed nominal systems for which the robust instability radius can be calculated exactly, and the other is a numerically tractable procedure for calculating the exact robust instability radius for nominal systems parametrized by a perturbation parameter. The results are applied to the repressilator in synthetic biology, where hyperbolic instability of a unique equilibrium guarantees the persistence of oscillation phenomena in the global sense, and the effectiveness of our linear robust instability analysis is confirmed by numerical simulations.

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Cited in

(1)

• Robust stability analysis for LTI systems with generalized frequency variables and its application to gene regulatory networks

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