Introduction to Statistical Methods in Modern Genetics

DOI10.1201/B16979MaRDI QIDQ4515054zbMATH OpenOpenAlexFDO

Authors Mark C. K. Yang

Publication date 9 November 2000

Full work available at URL https://doi.org/10.1201/b16979

zbMATH Keywords

computer programsexerciseslinkage analysisqualitative traitsquantitative traits

Mathematics Subject Classification ID

Introductory exposition (textbooks, tutorial papers, etc.) pertaining to statistics (62-01) Applications of statistics to biology and medical sciences; meta analysis (62P10) Epidemiology (92D30)

Review text

The importance of genetics can be felt almost daily. The topics chosen by the author are undoubtfully biased; however, let us quote why: `` ... these are the topics I wanted to know more about when I got into this field, and I hope that many beginners will share the same interest in them\dots. The topics include \(\bullet\) How is a gene found? \(\bullet\) How have scientists separated the genetic and environmental aspects of a person's intelligence? \(\bullet\) How has genetics been used in agriculture so that the domestic animals and crops are constantly improved? \(\bullet\) What is a DNA fingerprint and why there are controversies about it? \(\bullet\) How did they use genes to rebuilt the evolutionary history? The author believes to understand them and hopes that in this book the readers will find no gaps in how these questions are answered. The book is written mainly for statistics students and therefore a certain statistical background going beyond elementary statistics is assumed. The author hopes that one year of graduate studies in most statistical departments should be sufficient. Contents: 1. Background to modern statistical genetics. 2. Linkage analysis with qualitative traits. 3. Genetics of quantitative traits. 4. Special topics. Appendix A: Statistical results useful in genetics. Appendix B: Selected public domain computer programs for genetic data analysis. Answers or hints to exercises. Bibliography. Index.

Recommendations

• The fundamentals of modern statistical genetics
• Some statistical methods in genetics
• Statistical methods in human genetics
• Some statistical models, methods and applications in genetics
• Mathematical and statistical methods for genetic analysis
• Statistical methods in genetics: from microarrays to genetic epidemiology -- an overview
• Statistics in genetics

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(12)

• Mathematical and statistical methods for genetic analysis.
• Kontsevich-Witten model from \(2+1\) gravity: new exact combinatorial solution
• Mini-workshop: Recent developments in statistical methods with applications to genetics and genomics. Abstracts from the mini-workshop held November 8--14, 2015
• Statistics and its applications to agriculture and genetics
• Principles of statistical genomics
• scientific article; zbMATH DE number 48189 (Why is no real title available?)
• scientific article; zbMATH DE number 193680 (Why is no real title available?)
• scientific article; zbMATH DE number 1082452 (Why is no real title available?)
• scientific article; zbMATH DE number 872083 (Why is no real title available?)
• A statistical approach to genetic epidemiology. Concepts and application. With a foreword by Robert C. Elston.
• Statistical genetics in traditionally cultivated crops
• The EM algorithm and the rise of computational biology

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