Mathematical and statistical methods for genetic analysis
This book fills an important gap by covering in a unified setting topics dispersed in the research literature. The main purpose is the use of statistical (and mathematical) methods in genetic research, including human genetics (genetic counselling, genetic epidemiology, etc.) The book requires reasonable knowledge of basic probability and theoretical statistics (particularly likelihood), as well as multivariate statistics. Some knowledge of stochastic processes is also required for some items. It includes what one may call crash courses in population and molecular genetics, likelihood maximization methods (EM algorithm included), and in Markov Chain Monte Carlo methods. The exercises are useful complements. The book concentrates on ideas and is very demanding to the reader, who has to fill in the details. Other topics covered are: allele frequency estimation, design of linkage experiments, genetic identity coefficients and their applications (genotype prediction, genetic model discrimination, quantitative genetics, etc.), pedigree analysis, polygamic model and applications, reconstruction of evolutionary trees, radiation hybrid mapping, models of recombination, Poisson approximation and application to DNA mapping.
- Mathematical and statistical methods for genetic analysis.
- Effective sample size: quick estimation of the effect of related samples in genetic case-control association analyses
- Erlang renewal models for genetic recombination
- Using the partitioning principle to construct confidence sets for the location of a disease gene
- A Markov model of polygenic inheritance
- Nonspecific probe binding and automatic gating in flow cytometry and fluorescence activated cell sorting (FACS)
- On the heterozygosity of an admixed population
- Non-identifiability of identity coefficients at biallelic loci
- A Markov chain sampler for contingency table exact inference
- Statistical genetics of quantitative traits. Linkage, maps, and QTL.
- Statistical inference from genetic data on pedigrees
- Statistics in human genetics and molecular biology.
- scientific article; zbMATH DE number 193680 (Why is no real title available?)
- scientific article; zbMATH DE number 1064369 (Why is no real title available?)
- scientific article; zbMATH DE number 1082452 (Why is no real title available?)
- Introduction to Statistical Methods in Modern Genetics
- A Review of Statistical Methods for Genome Mapping
- Linkage Disequilibrium Mapping of Disease Susceptibility Genes in Human Populations
- MCMC Estimation of Multi‐locus Genome Sharing and Multipoint Gene Location Scores
- scientific article; zbMATH DE number 1405849 (Why is no real title available?)
- Analysis of genetic risk assessment methods
- Exponential family models and statistical genetics
- Genetics and Insurance: What have we Learned So Far?
- Sequence Robust Association Test for Familial Data
- Statistical analysis in genetic studies of mental illnesses
- A project of applied statistical methods in China: review and outlook
- Likelihood, Bayesian, and MCMC methods in quantitative genetics
- Coalescent process with fluctuating population size and its effective size
- Block designs for random treatment effects
- The statistics of gene mapping
- Penalized cluster analysis with applications to family data
- The fundamentals of modern statistical genetics
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