Modular control of Boolean network models

DOI10.1007/S11538-025-01471-9MaRDI QIDQ6952305zbMATH OpenFDO

Authors David Murrugarra, Alan Veliz-Cuba, Elena S. Dimitrova, C. Kadelka, Matthew W. Wheeler, Reinhard Laubenbacher

Publication date 28 July 2025

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/S11538-025-01471-9

zbMATH Keywords

Boolean networkscanalizationcontrolgene regulatory networksmodularity

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Boolean control/observation systems (93C29)

Review text

In the ``Modular control of Boolean network models paper the authors address the task and challenge of predicting gene regulation and linking it in a functional manner to singalling and other metabolic mechanisms. They propose a framework, relying on Boolean networks and decompositions on canonical semidirect product, for exporing modularity. Following a comprehensive overview of theoretical concepts related to Boolean networks, the authors move on to regulatory modules, and approaches for controlling the properties of the nextwork via modularity parameters and canalization. Blood cancer large granular lymphocyte (TLGL) leukemia is presented as case study.

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