Optimization-based approaches to control of probabilistic Boolean networks
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Summary: Control of gene regulatory networks is one of the fundamental topics in systems biology. In the last decade, control theory of Boolean networks (BNs), which is well known as a model of gene regulatory networks, has been widely studied. In this review paper, our previously proposed methods on optimal control of probabilistic Boolean networks (PBNs) are introduced. First, the outline of PBNs is explained. Next, an optimal control method using polynomial optimization is explained. The finite-time optimal control problem is reduced to a polynomial optimization problem. Furthermore, another finite-time optimal control problem, which can be reduced to an integer programming problem, is also explained.
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Cited in
(24)- Finite-horizon LQR controller for partially-observed Boolean dynamical systems
- Optimal intervention in semi-Markov-based asynchronous probabilistic Boolean networks
- A probabilistic approach to control of complex systems and its application to real-time pricing
- Optimal control algorithms for switched Boolean network
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