Protocol Designed Subgroup Analyses in Multiarmed Clinical Trials: Multiplicity Aspects

DOI10.1081/BIP-120024201MaRDI QIDQ4430341zbMATH OpenWikidataFDO

Authors Egbert H. E. Biesheuvel, Ludwig A. Hothorn

Publication date 7 October 2003

Published in Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1081/BIP-120024201

Mathematics Subject Classification ID

Sequential statistical design (62L05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• P-value adjustments for fubgroup analyses
• Multiple analyses in clinical trials. Fundamentals for investigators
• Multiplicity considerations for subgroup analysis subject to consistency constraint
• A Bayesian subgroup analysis using collections of ANOVA models
• Exploratory subgroup analysis in clinical trials by model selection

Cites work

• Analyzing Randomized Dose Finding Studies with a Primary and a Secondary Endpoint
• scientific article; zbMATH DE number 1241143 (Why is no real title available?)
• scientific article; zbMATH DE number 1741808 (Why is no real title available?)
• Multiparameter Hypothesis Testing and Acceptance Sampling
• Numerical computation of multivariatet-probabilities with application to power calculation of multiple contrasts
• On the numerical availability of multiple comparison procedures
• Optimally weighted, fixed sequence and gatekeeper multiple testing procedures

Cited in

(3)

• Multiple analyses in clinical trials. Fundamentals for investigators
• Panel forum on multiple comparison procedures: A commentary from a complex trial design and analysis plan
• Multiplicity considerations for subgroup analysis subject to consistency constraint

Describes a project that uses

Uses Software

• SAS

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