Lie group action and stability analysis of stationary solutions for a free boundary problem modelling tumor growth

DOI10.1016/J.JDE.2008.10.014zbMATH Open1168.35048arXiv0712.2483OpenAlexW2050589617MaRDI QIDQ1007259FDOQ1007259

Shangbin Cui

Publication date: 20 March 2009

Published in: Journal of Differential Equations (Search for Journal in Brave)

Abstract: In this paper we study asymptotic behavior of solutions for a multidimensional free boundary problem modelling the growth of nonnecrotic tumors. We first establish a general result for differential equations in Banach spaces possessing a local Lie group action which maps a solution into new solutions. We prove that a center manifold exists under certain assumptions on the spectrum of the linearized operator without assuming that the space in which the equation is defined is of either $D_A(heta)$ or $D_A(heta,infty)$ type. By using this general result and making delicate analysis of the spectrum of the linearization of the stationary free boundary problem, we prove that if the surface tension coefficient $gamma$ is larger than a threshold value $gamm{a}^{a}st$ then the unique stationary solution is asymptotically stable modulo translations, provided the constant $c$ representing the ratio between the nutrient diffusion time and the tumor-cell doubling time is sufficiently small, whereas if $gamma<gamm{a}^{a}st$ then this stationary solution is unstable.

Full work available at URL: https://arxiv.org/abs/0712.2483

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zbMATH Keywords

asymptotic stabilityfree boundary problemtumor growthcenter manifoldlocal Lie group

Mathematics Subject Classification ID

Stability in context of PDEs (35B35) Asymptotic behavior of solutions to PDEs (35B40) Free boundary problems for PDEs (35R35) Semigroups of nonlinear operators (47H20) Biomechanics (92C10)

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Cited In (19)

• Asymptotic stability for a free boundary tumor model with a periodic supply of external nutrients
• Asymptotic stability for a free boundary tumor model with angiogenesis
• On convergence of solutions to equilibria for quasilinear parabolic problems
• Analysis of a free boundary problem modeling the growth of multicell spheroids with angiogenesis
• Global existence for a mathematical model of the immune response to cancer
• Stationary solutions of a free boundary problem modeling the growth of tumors with Gibbs-Thomson relation
• Well-posedness and stability for an elliptic-parabolic free boundary problem modeling the growth of multi-layer tumors
• Analysis of a radial free boundary tumor model with time-dependent absorption efficiency
• Asymptotic behavior of solutions of a free-boundary tumor model with angiogenesis
• Mathematical analysis on a diffusion model describing the compatibility between two types of tumor cells
• Analysis of a free boundary problem modeling the growth of spherically symmetric tumors with angiogenesis
• Regularity of solutions to a free boundary problem modeling tumor growth by Stokes equation
• Analyticity of solutions to a free boundary problem modeling the growth of multi-layer tumors
• Analysis of a nonlinear necrotic tumor model with two free boundaries
• Analysis of a tumor-model free boundary problem with a nonlinear boundary condition
• On the Banach manifold of simple domains in the Euclidean space and applications to free boundary problems
• Asymptotic behavior of solutions of a free boundary problem modeling the growth of tumors with fluid-like tissue under the action of inhibitors
• Analysis of a high-dimensional free boundary problem on tumor growth with time-dependent nutrient supply and inhibitor action
• Asymptotic behavior of solutions of a free boundary problem modeling tumor spheroid with Gibbs-Thomson relation

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