Asymptotic stability for a free boundary tumor model with a periodic supply of external nutrients

DOI10.1016/J.NONRWA.2021.103466zbMATH Open1485.35434arXiv2109.14823OpenAlexW3216103298MaRDI QIDQ2113875FDOQ2113875

Yaodan Huang

Publication date: 14 March 2022

Published in: Nonlinear Analysis. Real World Applications (Search for Journal in Brave)

Abstract: For tumor growth, the morphological instability provides a mechanism for invasion via tumor fingering and fragmentation. This work considers the asymptotic stability of a free boundary tumor model with a periodic supply of external nutrients. The model consists of two elliptic equations describing the concentration of nutrients and the distribution of the internal pressure in the tumor tissue, respectively. The effect of the parameter $mu$ representing a measure of mitosis on the morphological stability are taken into account. It was recently established in [25] that there exists a critical value $m{u}_{a}st$ such that the unique spherical periodic positive solution is linearly stable for $0<mu<m{u}_{a}st$ and linearly unstable for $mu>m{u}_{a}st$. In this paper, we further prove that the spherical periodic positive solution is asymptotically stable for $0<mu<m{u}_{a}st$ for the fully nonlinear problem.

Full work available at URL: https://arxiv.org/abs/2109.14823

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zbMATH Keywords

free boundary problemsnonlinear stabilityperiodic solutiontumor growth

Mathematics Subject Classification ID

Medical applications (general) (92C50) Stability in context of PDEs (35B35) Asymptotic behavior of solutions to PDEs (35B40) Periodic solutions to PDEs (35B10) Free boundary problems for PDEs (35R35)

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Cited In (5)

• Tumor boundary instability induced by nutrient consumption and supply
• Linear stability for a free boundary tumor model with a periodic supply of external nutrients
• Analysis of a high-dimensional free boundary problem on tumor growth with time-dependent nutrient supply and inhibitor action
• Free boundary limit of a tumor growth model with nutrient
• Analysis of a free boundary problem modeling spherically symmetric tumor growth with angiogenesis and a periodic supply of nutrients

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