Asymptotic stability for a free boundary tumor model with a periodic supply of external nutrients

DOI10.1016/J.NONRWA.2021.103466MaRDI QIDQ2113875zbMATH OpenOpenAlexFDO

Authors Yaodan Huang

Publication date 14 March 2022

Published in Nonlinear Analysis. Real World Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2109.14823

zbMATH Keywords

free boundary problemsnonlinear stabilityperiodic solutiontumor growth

Mathematics Subject Classification ID

Medical applications (general) (92C50) Stability in context of PDEs (35B35) Asymptotic behavior of solutions to PDEs (35B40) Periodic solutions to PDEs (35B10) Free boundary problems for PDEs (35R35)

Abstract: For tumor growth, the morphological instability provides a mechanism for invasion via tumor fingering and fragmentation. This work considers the asymptotic stability of a free boundary tumor model with a periodic supply of external nutrients. The model consists of two elliptic equations describing the concentration of nutrients and the distribution of the internal pressure in the tumor tissue, respectively. The effect of the parameter $mu$ representing a measure of mitosis on the morphological stability are taken into account. It was recently established in [25] that there exists a critical value $m{u}_{a}st$ such that the unique spherical periodic positive solution is linearly stable for $0<mu<m{u}_{a}st$ and linearly unstable for $mu>m{u}_{a}st$. In this paper, we further prove that the spherical periodic positive solution is asymptotically stable for $0<mu<m{u}_{a}st$ for the fully nonlinear problem.

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Cited in

(6)

• Analysis of a free boundary problem modeling spherically symmetric tumor growth with angiogenesis and a periodic supply of nutrients
• Tumor boundary instability induced by nutrient consumption and supply
• Asymptotic stability for a free boundary problem arising in a tumor model
• Free boundary limit of a tumor growth model with nutrient
• Linear stability for a free boundary tumor model with a periodic supply of external nutrients
• Analysis of a high-dimensional free boundary problem on tumor growth with time-dependent nutrient supply and inhibitor action

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