Degenerate diffusions arising from gene duplication models

DOI10.1214/08-AAP530MaRDI QIDQ1009477zbMATH OpenOpenAlexFDO

Authors Lea Popovic, Rick Durrett

Publication date 2 April 2009

Published in The Annals of Applied Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0902.4780

zbMATH Keywords

Lyapunov functionone-dimensional diffusionsgene duplicationsubfunctionalization

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Problems related to evolution (92D15) Protein sequences, DNA sequences (92D20) Diffusion processes (60J60)

Abstract: We consider two processes that have been used to study gene duplication, Watterson's [Genetics 105 (1983) 745--766] double recessive null model and Lynch and Force's [Genetics 154 (2000) 459--473] subfunctionalization model. Though the state spaces of these diffusions are two and six-dimensional, respectively, we show in each case that the diffusion stays close to a curve. Using ideas of Katzenberger [Ann. Probab. 19 (1991) 1587--1628] we show that one-dimensional projections converge to diffusion processes, and we obtain asymptotics for the time to loss of one gene copy. As a corollary we find that the probability of subfunctionalization decreases exponentially fast as the population size increases. This rigorously confirms a result Ward and Durrett [Theor. Pop. Biol. 66 (2004) 93--100] found by simulation that the likelihood of subfunctionalization for gene duplicates decays exponentially fast as the population size increases.

Recommendations

• A diffusion model for the fate of tandem gene duplicates in diploids
• A diffusion approach to approximating preservation probabilities for gene duplicates
• Subfunctionalization: How often does it occur? How long does it take?
• Dual processes and an invariance result for exchangeable models in population genetics
• Models for loosely linked gene duplicates suggest lengthy persistence of both copies

Cites work

• scientific article; zbMATH DE number 42093 (Why is no real title available?)
• Average time until fixation of a mutant allele in a finite population under continued mutation pressure: Studies by analytical, numerical, and pseudo-sampling methods
• Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift.
• Solutions of a stochastic differential equation forced onto a manifold by a large drift
• Stochastic Calculus
• Subfunctionalization: How often does it occur? How long does it take?
• Weak limit theorems for stochastic integrals and stochastic differential equations

Cited in

(10)

• Models for loosely linked gene duplicates suggest lengthy persistence of both copies
• A diffusion model for the fate of tandem gene duplicates in diploids
• Level-dependent QBD models for the evolution of a family of gene duplicates
• The diversity of a distributed genome in bacterial populations
• Diffusion dynamics on the coexistence subspace in a stochastic evolutionary game
• On the retention of gene duplicates prone to dominant deleterious mutations
• scientific article; zbMATH DE number 3902455 (Why is no real title available?)
• Features of fast living: on the weak selection for longevity in degenerate birth-death processes
• Dimension reduction for stochastic dynamical systems forced onto a manifold by large drift: a constructive approach with examples from theoretical biology
• A diffusion approach to approximating preservation probabilities for gene duplicates

This page was built for publication: Degenerate diffusions arising from gene duplication models

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1009477)