On the retention of gene duplicates prone to dominant deleterious mutations

DOI10.1016/J.TPB.2014.01.004MaRDI QIDQ743527zbMATH OpenOpenAlexWikidataFDO

Authors Giulia Malaguti, Param Priya Singh, Hervé Isambert

Publication date 24 September 2014

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://zenodo.org/record/895351

zbMATH Keywords

dominant deleterious mutationspopulation genetics modelspurifying selectionsmall scale duplicationwhole-genome duplication

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Population dynamics (general) (92D25)

Recommendations

• A diffusion model for the fate of tandem gene duplicates in diploids
• Role of selection in fixation of gene duplications
• Models for loosely linked gene duplicates suggest lengthy persistence of both copies
• Degenerate diffusions arising from gene duplication models
• A diffusion approach to approximating preservation probabilities for gene duplicates

Cites work

• A coalescent dual process in a Moran model with genic selection
• A coalescent dual process in a Moran model with genic selection, and the lambda coalescent limit
• scientific article; zbMATH DE number 3140919 (Why is no real title available?)
• scientific article; zbMATH DE number 3657493 (Why is no real title available?)
• scientific article; zbMATH DE number 3806623 (Why is no real title available?)
• scientific article; zbMATH DE number 3273551 (Why is no real title available?)
• Role of selection in fixation of gene duplications
• The allele-frequency spectrum in a decoupled Moran model with mutation, drift, and directional selection, assuming small mutation rates

Cited in

(1)

• Role of selection in fixation of gene duplications

Describes a project that uses

Uses Software

• GeneCards
• UniProt
• PSI-BLAST
• BLAST

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