Identification of relevant subtypes via preweighted sparse clustering

DOI10.1016/J.CSDA.2017.06.003zbMATH Open1466.62074DBLPjournals/csda/GaynorB17arXiv1304.3760OpenAlexW2962943190WikidataQ88765096 ScholiaQ88765096MaRDI QIDQ1658409FDOQ1658409

Authors: Sheila Gaynor, Eric Bair Edit this on Wikidata

Publication date: 14 August 2018

Published in: Computational Statistics and Data Analysis (Search for Journal in Brave)

Abstract: Cluster analysis methods are used to identify homogeneous subgroups in a data set. In biomedical applications, one frequently applies cluster analysis in order to identify biologically interesting subgroups. In particular, one may wish to identify subgroups that are associated with a particular outcome of interest. Conventional clustering methods generally do not identify such subgroups, particularly when there are a large number of high-variance features in the data set. Conventional methods may identify clusters associated with these high-variance features when one wishes to obtain secondary clusters that are more interesting biologically or more strongly associated with a particular outcome of interest. A modification of sparse clustering can be used to identify such secondary clusters or clusters associated with an outcome of interest. This method correctly identifies such clusters of interest in several simulation scenarios. The method is also applied to a large prospective cohort study of temporomandibular disorders and a leukemia microarray data set.

Full work available at URL: https://arxiv.org/abs/1304.3760

Recommendations

• Biclustering via sparse clustering
• A framework for feature selection in clustering
• Clustering Objects on Subsets of Attributes (with Discussion)
• Bayesian variable selection in clustering high-dimensional data with substructure
• Sparse integrative clustering of multiple omics data sets

zbMATH Keywords

cancercluster analysishigh-dimensional datak-means clusteringtemporomandibular disorders

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• A framework for feature selection in clustering
• Estimating the number of clusters in a data set via the gap statistic
• Penalized model-based clustering with application to variable selection
• Clustering Objects on Subsets of Attributes (with Discussion)
• Title not available (Why is that?)
• Variable Selection for Model-Based Clustering
• Finding the Number of Clusters in a Dataset
• Prediction by Supervised Principal Components
• Complementary hierarchical clustering

Cited In (7)

• Subpopulation discovery in epidemiological data with subspace clustering
• Biclustering via sparse clustering
• Robust clustering with subpopulation-specific deviations
• Multiobjective semisupervised learning with a right‐censored endpoint adapted to the multiple imputation framework
• Nonparametric cluster significance testing with reference to a unimodal null distribution
• A method for visual identification of small sample subgroups and potential biomarkers
• Biclustering with heterogeneous variance

Uses Software

• glmnet
• sparcl
• compHclust
• COSA

This page was built for publication: Identification of relevant subtypes via preweighted sparse clustering

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1658409)