Nonlinear statistical data assimilation for HVC_RA neurons in the Avian song system

DOI10.1007/S00422-016-0697-3MaRDI QIDQ1693763zbMATH OpenOpenAlexWikidataFDO

Authors Nirag Kadakia, Eve Armstrong, Daniel Breen, Arij Daou, Daniel Margoliash, Henry D. I. Abarbanel, Uriel I. Morone

Publication date 31 January 2018

Published in Biological Cybernetics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1608.04005

zbMATH Keywords

data assimilationdynamical systemsion channel propertiesneuronal dynamicsparameter estimationsong systemspiking neuron models

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) General biostatistics (92B15) Neural biology (92C20) Animal behavior (92D50)

Abstract: With the goal of building a model of the HVC nucleus in the avian song system, we discuss in detail a model of HVC${}_{extRA}$ projection neurons comprised of a somatic compartment with fast Na${}^{+}$ and K${}^{+}$ currents and a dendritic compartment with slower Ca${}^{2+}$ dynamics. We show this model qualitatively exhibits many observed electrophysiological behaviors. We then show in numerical procedures how one can design and analyze feasible laboratory experiments that allow the estimation of all of the many parameters and unmeasured dynamical variables, given observations of the somatic voltage $V_s(t)$ alone. A key to this procedure is to initially estimate the slow dynamics associated with Ca, blocking the fast Na and K variations, and then with the Ca parameters fixed, estimate the fast Na and K dynamics. This separation of time scales provides a numerically robust method for completing the full neuron model, and the efficacy of the method is tested by prediction when observations are complete. The simulation provides a framework for the slice preparation experiments and illustrates the use of data assimilation methods for the design of those experiments.

Recommendations

• Dynamical estimation of neuron and network properties. I: Variational methods
• A unifying view of synchronization for data assimilation in complex nonlinear networks
• Data assimilation methods for neuronal state and parameter estimation
• A nonlinear autoregressive Volterra model of the Hodgkin-Huxley equations
• Dynamical estimation of neuron and network properties. II: Path integral Monte Carlo methods

Cites work

• Accurate state and parameter estimation in nonlinear systems with sparse observations
• Dynamical estimation of neuron and network properties. I: Variational methods
• Dynamical estimation of neuron and network properties. II: Path integral Monte Carlo methods
• scientific article; zbMATH DE number 976341 (Why is no real title available?)
• Mathematical foundations of neuroscience
• On the implementation of an interior-point filter line-search algorithm for large-scale nonlinear programming
• Predicting the future. Completing models of observed complex systems

Cited in

(6)

• Data assimilation methods for neuronal state and parameter estimation
• Special issue from the 2017 international conference on mathematical neuroscience
• Predicting the behavior of sparsely-sampled systems across neurobiology and epidemiology
• Model selection of chaotic systems from data with hidden variables using sparse data assimilation
• Dynamical estimation of neuron and network properties. I: Variational methods
• On temporal scale separation in coupled data assimilation with the ensemble Kalman filter

Describes a project that uses

Uses Software

• Ipopt

This page was built for publication: Nonlinear statistical data assimilation for \(\mathrm{HVC}_{\mathrm{RA}}\) neurons in the Avian song system

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1693763)