Hypoxic cell waves around necrotic cores in glioblastoma: a biomathematical model and its therapeutic implications

DOI10.1007/S11538-012-9786-1zbMATH Open1264.92028arXiv1204.3809OpenAlexW2074614782WikidataQ41883885 ScholiaQ41883885MaRDI QIDQ1936688FDOQ1936688

Authors: Alicia Martínez-González, Gabriel F. Calvo, Luis A. Pérez Romasanta, Víctor M. Pérez-García 

Publication date: 6 February 2013

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hiperplasia. Necrotic areas are typically surrounded by hypercellular regions known as "pseudopalisades" originated by local tumor vessel occlusions that induce collective cellular migration events. This leads to the formation of waves of tumor cells actively migrating away from central hypoxia. We present a mathematical model that incorporates the interplay among two tumor cell phenotypes, a necrotic core and the oxygen distribution. Our simulations reveal the formation of a traveling wave of tumor cells that reproduces the observed histologic patterns of pseudopalisades. Additional simulations of the model equations show that preventing the collapse of tumor microvessels leads to slower glioma invasion, a fact that might be exploited for therapeutic purposes.

Full work available at URL: https://arxiv.org/abs/1204.3809

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zbMATH Keywords

invasionglioblastoma multiformetumor hypoxiapseudopalisades

Mathematics Subject Classification ID

Medical applications (general) (92C50) Dynamical systems in biology (37N25) Probabilistic models, generic numerical methods in probability and statistics (65C20)

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Cited In (35)

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• Stochastic modelling of slow-progressing tumors: analysis and applications to the cell interplay and control of low grade gliomas
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• Tumor width on T1-weighted MRI images of glioblastoma as a prognostic biomarker: a mathematical model
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