Analysis of a tumor model free boundary problem with action of an inhibitor and nonlinear boundary conditions

DOI10.1016/J.JMAA.2020.124793MaRDI QIDQ1996902zbMATH OpenOpenAlexFDO

Authors Jiayue Zheng, Shangbin Cui

Publication date 28 February 2021

Published in Journal of Mathematical Analysis and Applications (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jmaa.2020.124793

zbMATH Keywords

free boundary probleminhibitorlarge-time behaviournonlinear boundary conditiontumor growth

Mathematics Subject Classification ID

Asymptotic behavior of solutions to PDEs (35B40) Nonlinear initial, boundary and initial-boundary value problems for linear parabolic equations (35K60) Free boundary problems for PDEs (35R35) General biology and biomathematics (92B05)

Review text

This paper deals with a free boundary problem modeling the growth of a spherically symmetric tumor. The model takes into account the influence of the inhibitory materials which the tumor receives from the host tissue. The unknowns are radius of the tumor, concentration of nutrient and concentration of inhibitor in the tumor. This model contains a nonlinear boundary condition which leads to additional difficulties in the study. Local existence of a classical solution is proved with the help of Banach fixed point theorem. The authors establish the global well-posedness of the problem and give the careful analysis for the large-time behaviour of the solution. Sufficient conditions are given for the case when the tumor is finally disappear and for the case when the tumor can not disappear in a finite time. Under the additional assumption that mutual action between nutrient and inhibitor is small, the existence of at least one stationary solution for the model is established. Sufficient condition for the asymptotic stability of the stationary solution is given.

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Cited in

(14)

• Analysis of a mathematical model of the effect of inhibitors on the growth of tumors
• Bifurcation analysis of a tumor-model free boundary problem with a nonlinear boundary condition
• Analysis of a tumor-model free boundary problem with a nonlinear boundary condition
• Analysis of a free boundary problem modeling tumor growth
• Analysis of a free boundary problem modeling multi-layer tumor growth in presence of inhibitor
• Asymptotic analysis of vascularized tumor growth model with inhibitor
• Global existence for a free boundary problem modelling the growth of necrotic tumors in the presence of inhibitors
• Asymptotic behavior of solutions for a free boundary problem modeling tumor growth
• Asymptotic behavior of solutions of a free boundary problem modeling multi-layer tumor growth in presence of inhibitor
• Asymptotic analyses and error estimates for a Cahn-Hilliard type phase field system modelling tumor growth
• Analysis of a mathematical model for tumor growth with Gibbs-Thomson relation
• A mathematical model of stroma-supported allometric tumor growth
• Analysis of a free boundary tumor model with time-dependent in the presence of inhibitors
• Analysis of a high-dimensional free boundary problem on tumor growth with time-dependent nutrient supply and inhibitor action

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