Stability analysis of regular and chaotic Ca^2+ oscillations in astrocytes

DOI10.1155/2020/9279315MaRDI QIDQ2004207zbMATH OpenOpenAlexFDO

Authors Min Ye, Hongkun Zuo

Publication date 14 October 2020

Published in Discrete Dynamics in Nature and Society (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2020/9279315

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) Neural biology (92C20)

Review text

Summary: \(\mathrm{Ca^{2+}}\) oscillations play an important role in various cell types. Thus, understanding the dynamical mechanisms underlying astrocytic \(\mathrm{Ca^{2+}}\) oscillations is of great importance. The main purpose of this article was to investigate dynamical behaviors and bifurcation mechanisms associated with astrocytic \(\mathrm{Ca^{2+}}\) oscillations, including stability of equilibrium and classification of different dynamical activities including regular and chaotic \(\mathrm{Ca^{2+}}\) oscillations. Computation results show that part of the reason for the appearance and disappearance of spontaneous astrocytic \(\mathrm{Ca^{2+}}\) oscillations is that they embody the subcritical Hopf and the supercritical Hopf bifurcation points. In more details, we theoretically analyze the stability of the equilibrium points and illustrate the regular and chaotic spontaneous calcium firing activities in the astrocytes model, which are qualitatively similar to actual biological experiment. Then, we investigate the effectiveness and the accuracy of our nonlinear dynamical mechanism analysis via computer simulations. These results suggest the important role of spontaneous \(\mathrm{Ca^{2+}}\) oscillations in conjunction with the adjacent neuronal input that may help correlate the connection of both the glia and neuron.

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Cites work

• A mathematical model of spontaneous calcium(II) oscillations in astrocytes
• Bursting oscillations, bifurcation and synchronization in neuronal systems
• Simulating, Analyzing, and Animating Dynamical Systems

Cited in

(10)

• A mathematical model of spontaneous calcium(II) oscillations in astrocytes
• Mixed-mode oscillations in a three-store calcium dynamics model
• A new real-time analog circuit of Ca\(^{2+}\) Li-Rinzel astrocyte model based on analytical method
• Contribution of calcium fluxes to astrocyte spontaneous calcium oscillations in deterministic and stochastic models
• Oscillatory activity in cells: multi-stability and hysteresis
• Calcium oscillations in astrocytes. Part 1: Astrocyte as generator of calcium oscillations
• Calcium oscillations in astrocytes. Part 2. Dynamics of interacting calcium oscillators
• Dynamical analysis of the neuronal Chay model
• Computation and stability analysis of Hopf bifurcation in biophysical system model of cells
• Dynamic mechanism of multiple bursting patterns in a whole-cell multiscale model with calcium oscillations

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