The FRiND model: a mathematical model for representing macrophage plasticity in muscular dystrophy pathogenesis

DOI10.1007/S11538-019-00635-8MaRDI QIDQ2008255zbMATH OpenOpenAlexWikidataFDO

Authors Matthew T. Houston, Juan Gutiérrez

Publication date 22 November 2019

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/s11538-019-00635-8

zbMATH Keywords

immunologyLGMDmathematical modelsMDmuscle repairmuscular dystrophyordinary differential equationssystems biology

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) Pathology, pathophysiology (92C32) Systems biology, networks (92C42)

Review text

It is considered the mathematical modeling of ``macrophage plasticity in muscular dystrophy pathogenesis. Starting from functional dependencies diagram and based on mass action law, there is obtained a model described by 10 nonlinear ordinary differential equations with 20 parameters whose estimation from real data is also described in the paper. However, since a prime integral is pointed out, the number of the equations can be lowered by 1. There are emphasized two equilibria -- physically significant -- with nonnegative components. One of them is exponentially stable (by the first approximation) while the other is of the type saddle point i.e. finally unstable. The model appears also to be fitted to experimental data.

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Cites work

• `` Direct Search Solution of Numerical and Statistical Problems
• Determining identifiable parameter combinations using subset profiling
• Generalization of the Rank and Order Conditions for Identifiability
• scientific article; zbMATH DE number 3766932 (Why is no real title available?)
• scientific article; zbMATH DE number 960162 (Why is no real title available?)
• Stability and phase transitions in a mathematical model of Duchenne muscular dystrophy

Cited in

(8)

• Stability and phase transitions in a mathematical model of Duchenne muscular dystrophy
• A mathematical model of skeletal muscle regeneration with upper body vibration
• A simple model of immune and muscle cell crosstalk during muscle regeneration
• A mathematical model of Duchenne muscular dystrophy
• A mathematical model of skeletal muscle regeneration
• The mathematical modeling behind Duchenne muscular dystrophy
• Polymyositis, Topological Proteomics Technology and Paradigm for Cell Invasion Dynamics
• Theoretical and numerical study of a skeletal muscle regeneration model with inflammatory response

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• COPASI

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