Virus-immune dynamics determined by prey-predator interaction network and epistasis in viral fitness landscape

DOI10.1007/S00285-022-01843-YMaRDI QIDQ2105313zbMATH OpenOpenAlexFDO

Authors Fadoua Yahia, Cameron J. Browne

Publication date 8 December 2022

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2106.08991

zbMATH Keywords

epistasisfitness landscapeeco-evolutionary dynamicsHIV quasispeciespredator-prey networkvirus-immune response model

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15) Systems biology, networks (92C42) Population dynamics (general) (92D25) Stability of solutions to ordinary differential equations (34D20)

Abstract: Population dynamics and evolutionary genetics underly the structure of ecosystems, changing on the same timescale for interacting species with rapid turnover, such as virus (e.g. HIV) and immune response. Thus, an important problem in mathematical modeling is to connect ecology, evolution and genetics, which often have been treated separately. Here, extending analysis of multiple virus and immune response populations in a resource - prey (consumer) - predator model from Browne and Smith cite{browne2018dynamics}, we show that long term dynamics of viral mutants evolving resistance at distinct epitopes (viral proteins targeted by immune responses) are governed by epistasis in the virus fitness landscape. In particular, the stability of persistent equilibrium virus-immune (prey-predator) network structures, such as nested and one-to-one, and bifurcations are determined by a collection of circuits defined by combinations of viral fitnesses that are minimally additive within a hypercube of binary sequences representing all possible viral epitope sequences ordered according to immunodominance hierarchy. Numerical solutions of our ordinary differential equation system, along with an extended stochastic version including random mutation, demonstrate how pairwise or multiplicative epistatic interactions shape viral evolution against concurrent immune responses and convergence to the multi-variant steady state predicted by theoretical results. Furthermore, simulations illustrate how periodic infusions of subdominant immune responses can induce a bifurcation in the persistent viral strains, offering superior host outcome over an alternative strategy of immunotherapy with strongest immune response.

Recommendations

• Dynamics of virus and immune response in multi-epitope network
• A mathematical model of dynamic interaction between virus and deleterious immunity response
• Epidemic dynamics and host immune response: a nested approach
• Dynamics of an immune-epidemiological model with virus evolution and superinfection
• Coevolutionary dynamics of host immune and parasite virulence based on an age-structured epidemic model
• A predator-prey-disease model with immune response in infected prey
• Thresholds and bistability in virus-immune dynamics
• Evolution of virulence driven by predator-prey interaction: possible consequences for population dynamics
• Immune networks modeled by replicator equations
• Parsimonious models of in-host viral dynamics and immune response

Cites work

• A singularly perturbed HIV model with treatment and antigenic variation
• Dynamics of virus and immune response in multi-epitope network
• Epistasis and shapes of fitness landscapes
• Evolutionary Games and Population Dynamics
• From adaptive dynamics to adaptive walks
• Measuring epistasis in fitness landscapes: the correlation of fitness effects of mutations
• Mechanisms of multi-strain coexistence in host-phage systems with nested infection networks
• Polymorphic evolution sequence and evolutionary branching
• Rigorous mathematical analysis of the quasispecies model: from Manfred Eigen to the recent developments
• Sector stability of a complex ecosystem model
• Stochastic eco-evolutionary model of a prey-predator community
• Successful invasion of a food web in a chemostat

Cited in

(7)

• Dynamics of virus and immune response in multi-epitope network
• A coupled evolutionary model of the viral virulence in an SIS community
• Existence and dynamics of strains in a nonlocal reaction-diffusion model of viral evolution
• Global properties of nested network model with application to multi-epitope HIV/CTL dynamics
• Analysis of a stochastic predator-prey model with applications to intrahost HIV genetic diversity
• Host-virus evolutionary dynamics with specialist and generalist infection strategies: bifurcations, bistability, and chaos
• Antigenic cooperation in viral populations: transformation of functions of intra-host viral variants

This page was built for publication: Virus-immune dynamics determined by prey-predator interaction network and epistasis in viral fitness landscape

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2105313)