A continuum mathematical model of substrate-mediated tissue growth

DOI10.1007/S11538-022-01005-7zbMATH Open1486.92081arXiv2111.07559OpenAlexW3212647944WikidataQ112320984 ScholiaQ112320984MaRDI QIDQ2113608FDOQ2113608

Authors: Maud El-Hachem, Scott W. McCue, Matthew J. Simpson 

Publication date: 14 March 2022

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: We consider a continuum mathematical model of biological tissue formation inspired by recent experiments describing thin tissue growth in 3D-printed bioscaffolds. The continuum model involves a partial differential equation describing the density of tissue, $hatu(hatmathbfx,hatt)$, that is coupled to the concentration of an immobile extracellular substrate, $hats(hatmathbfx,hatt)$. Cell migration is modelled with a nonlinear diffusion term, where the diffusive flux is proportional to $hats$, while a logistic growth term models cell proliferation. The extracellular substrate $hats$ is produced by cells, and undergoes linear decay. Preliminary numerical simulations show that this mathematical model, which we call the extit{substrate model}, is able to recapitulate key features of recent tissue growth experiments, including the formation of sharp fronts. To provide a deeper understanding of the model we then analyse travelling wave solutions of the substrate model, showing that the model supports both sharp-fronted travelling wave solutions that move with a minimum wave speed, $c=c_{mmin}$, as well as smooth-fronted travelling wave solutions that move with a faster travelling wave speed, $c>c_{mmin}$. We provide a geometric interpretation that explains the difference between smooth- and sharp-fronted travelling wave solutions that is based on a slow manifold reduction of the desingularised three-dimensional phase space. In addition to exploring the nature of the smooth- and sharp-fronted travelling waves, we also develop and test a series of useful approximations that describe the shape of the travelling wave solutions in various limits. These approximations apply to both the sharp-fronted travelling wave solutions, and the smooth-fronted travelling wave solutions. Software to implement all calculations is available on GitHub.

Full work available at URL: https://arxiv.org/abs/2111.07559

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zbMATH Keywords

diffusionFisher-KPPtravelling wavetissue engineeringlogistic growthporous-Fisher

Mathematics Subject Classification ID

Medical applications (general) (92C50) Traveling wave solutions (35C07) Developmental biology, pattern formation (92C15)

Cites Work

• Mathematical biology. Vol. 1: An introduction.
• On a Nonlinear Diffusion Equation Describing Population Growth
• Explicit solutions of Fisher's equation for a special wave speed
• Introduction to Applied Nonlinear Dynamical Systems and Chaos
• An asymptotic solution for traveling waves of a nonlinear-diffusion Fisher's equation
• Nonsharp travelling wave fronts in the Fisher equation with degenerate nonlinear diffusion
• Modelling the movement of interacting cell populations
• Merging traveling waves for the porous-Fisher's equation
• A model for the spread of an invasive weed, \textit{Tradescantia fluminensis}
• Reproducibility of scratch assays is affected by the initial degree of confluence: experiments, modelling and model selection
• Asymptotic analysis. Reprint
• Using experimental data and information criteria to guide model selection for reaction-diffusion problems in mathematical biology
• An approximation to a sharp type solution of a density-dependent reaction-diffusion equation
• Travelling wave analysis of cellular invasion into surrounding tissues
• Title not available (Why is that?)
• Cell proliferation and oxygen diffusion in a vascularising scaffold
• Logistic proliferation of cells in scratch assays is delayed
• Mix and match: phenotypic coexistence as a key facilitator of cancer invasion
• New travelling wave solutions of the Porous–Fisher model with a moving boundary
• Model-based data analysis of tissue growth in thin 3D printed scaffolds
• Hole-closing model reveals exponents for nonlinear degenerate diffusivity functions in cell biology
• A Bayesian sequential learning framework to parameterise continuum models of melanoma invasion into human skin
• Propagation fronts in a simplified model of tumor growth with degenerate cross-dependent self-diffusivity
• A non-local cross-diffusion model of population dynamics II: exact, approximate, and numerical traveling waves in single- and multi-species populations
• Invading and receding sharp-fronted travelling waves

Cited In (4)

• A qualitative analysis of some models of tissue growth
• A continuum model of the growth of engineered epidermal skin substitutes
• Substrate_Mediated_Invasion
• A theoretical model for tissue growth in confined geometries

Uses Software

• GitHub

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