A continuum mathematical model of substrate-mediated tissue growth

DOI10.1007/S11538-022-01005-7zbMATH Open1486.92081arXiv2111.07559OpenAlexW3212647944WikidataQ112320984 ScholiaQ112320984MaRDI QIDQ2113608FDOQ2113608

Matthew J. Simpson, Maud El-Hachem, Scott W. McCue

Publication date: 14 March 2022

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: We consider a continuum mathematical model of biological tissue formation inspired by recent experiments describing thin tissue growth in 3D-printed bioscaffolds. The continuum model involves a partial differential equation describing the density of tissue, $hatu(hatmathbfx,hatt)$, that is coupled to the concentration of an immobile extracellular substrate, $hats(hatmathbfx,hatt)$. Cell migration is modelled with a nonlinear diffusion term, where the diffusive flux is proportional to $hats$, while a logistic growth term models cell proliferation. The extracellular substrate $hats$ is produced by cells, and undergoes linear decay. Preliminary numerical simulations show that this mathematical model, which we call the extit{substrate model}, is able to recapitulate key features of recent tissue growth experiments, including the formation of sharp fronts. To provide a deeper understanding of the model we then analyse travelling wave solutions of the substrate model, showing that the model supports both sharp-fronted travelling wave solutions that move with a minimum wave speed, $c=c_{mmin}$, as well as smooth-fronted travelling wave solutions that move with a faster travelling wave speed, $c>c_{mmin}$. We provide a geometric interpretation that explains the difference between smooth- and sharp-fronted travelling wave solutions that is based on a slow manifold reduction of the desingularised three-dimensional phase space. In addition to exploring the nature of the smooth- and sharp-fronted travelling waves, we also develop and test a series of useful approximations that describe the shape of the travelling wave solutions in various limits. These approximations apply to both the sharp-fronted travelling wave solutions, and the smooth-fronted travelling wave solutions. Software to implement all calculations is available on GitHub.

Full work available at URL: https://arxiv.org/abs/2111.07559

zbMATH Keywords

diffusionFisher-KPPtravelling wavetissue engineeringlogistic growthporous-Fisher

Mathematics Subject Classification ID

Medical applications (general) (92C50) Traveling wave solutions (35C07) Developmental biology, pattern formation (92C15)

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Cited In (4)

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Uses Software

• GitHub

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