A continuum mathematical model of substrate-mediated tissue growth

DOI10.1007/S11538-022-01005-7MaRDI QIDQ2113608zbMATH OpenOpenAlexWikidataFDO

Authors Maud El-Hachem, Scott W. McCue, Matthew J. Simpson

Publication date 14 March 2022

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2111.07559

zbMATH Keywords

diffusionFisher-KPPtravelling wavetissue engineeringlogistic growthporous-Fisher

Mathematics Subject Classification ID

Medical applications (general) (92C50) Traveling wave solutions (35C07) Developmental biology, pattern formation (92C15)

Abstract: We consider a continuum mathematical model of biological tissue formation inspired by recent experiments describing thin tissue growth in 3D-printed bioscaffolds. The continuum model involves a partial differential equation describing the density of tissue, $hatu(hatmathbfx,hatt)$, that is coupled to the concentration of an immobile extracellular substrate, $hats(hatmathbfx,hatt)$. Cell migration is modelled with a nonlinear diffusion term, where the diffusive flux is proportional to $hats$, while a logistic growth term models cell proliferation. The extracellular substrate $hats$ is produced by cells, and undergoes linear decay. Preliminary numerical simulations show that this mathematical model, which we call the extit{substrate model}, is able to recapitulate key features of recent tissue growth experiments, including the formation of sharp fronts. To provide a deeper understanding of the model we then analyse travelling wave solutions of the substrate model, showing that the model supports both sharp-fronted travelling wave solutions that move with a minimum wave speed, $c=c_{mmin}$, as well as smooth-fronted travelling wave solutions that move with a faster travelling wave speed, $c>c_{mmin}$. We provide a geometric interpretation that explains the difference between smooth- and sharp-fronted travelling wave solutions that is based on a slow manifold reduction of the desingularised three-dimensional phase space. In addition to exploring the nature of the smooth- and sharp-fronted travelling waves, we also develop and test a series of useful approximations that describe the shape of the travelling wave solutions in various limits. These approximations apply to both the sharp-fronted travelling wave solutions, and the smooth-fronted travelling wave solutions. Software to implement all calculations is available on GitHub.

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Cited in

(4)

• A theoretical model for tissue growth in confined geometries
• A qualitative analysis of some models of tissue growth
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• Substrate_Mediated_Invasion

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• GitHub

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