Mathematical modelling of OAS2 activation by dsRNA and effects of dsRNA lengths

DOI10.3934/MATH.2021351MaRDI QIDQ2133328zbMATH OpenOpenAlexFDO

Authors Deokro Lee, Amit Koul, Nikhat Lubna, Sean A. McKenna, Stéphanie Portet

Publication date 29 April 2022

Published in AIMS Mathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.3934/math.2021351

zbMATH Keywords

concentrationsdsRNAenzymatic activityenzyme activationlengthsmathematical modellingOAS2

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Dynamics of \textit{in vitro} intermediate filament length distributions
• Further analysis of the data by Akaike's information criterion and the finite corrections
• Model Selection and Multimodel Inference
• Regression and time series model selection in small samples

Cited in

(3)

• Mathematical modeling of the cGAS pathway reveals robustness of DNA sensing to TREX1 feedback
• A mathematical analysis of an activator-inhibitor Rho GTPase model
• Mechanistic modeling explains the dsRNA length-dependent activation of the RIG-I mediated immune response

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