A machine learning framework for predicting synergistic and antagonistic drug combinatorial efficacy

DOI10.1007/S10910-022-01331-0MaRDI QIDQ2143447zbMATH OpenOpenAlexFDO

Authors Suyu Mei

Publication date 31 May 2022

Published in Journal of Mathematical Chemistry (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s10910-022-01331-0

zbMATH Keywords

machine learningdrug-drug interactionsignaling pathwaysdrug combination

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Recommendations

• Detection of synergistic combinatorial perturbations by a bifurcation-based approach
• A similarity-based method for prediction of drug side effects with heterogeneous information
• Experimental design for multi-drug combination studies using signaling networks
• Genetic programming for anticancer therapeutic response prediction using the NCI-60 dataset
• In silico synergism and antagonism of an anti-tumour system intervened by coupling immunotherapy and chemotherapy: a mathematical modelling approach

Cites work

• A simple generalisation of the area under the ROC curve for multiple class classification problems
• LIBLINEAR: a library for large linear classification

Cited in

(3)

• Machine learning in drug development: characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and uncertainty quantification
• Multi-drug combination designs with experiments in silico
• A similarity-based method for prediction of drug side effects with heterogeneous information

Describes a project that uses

Uses Software

• DrugBank
• LIBLINEAR

This page was built for publication: A machine learning framework for predicting synergistic and antagonistic drug combinatorial efficacy

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2143447)