Inference for stochastic kinetic models from multiple data sources for joint estimation of infection dynamics from aggregate reports and virological data
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Publication:2154191
Abstract: Before the current pandemic, influenza and respiratory syncytial virus (RSV) were the leading etiological agents of seasonal acute respiratory infections (ARI) around the world. In this setting, medical doctors typically based the diagnosis of ARI on patients' symptoms alone and did not routinely conduct virological tests necessary to identify individual viruses, limiting the ability to study the interaction between multiple pathogens and to make public health recommendations. We consider a stochastic kinetic model (SKM) for two interacting ARI pathogens circulating in a large population and an empirically-motivated background process for infections with other pathogens causing similar symptoms. An extended marginal sampling approach, based on the linear noise approximation to the SKM, integrates multiple data sources and additional model components. We infer the parameters defining the pathogens' dynamics and interaction within a Bayesian model and explore the posterior trajectories of infections for each illness based on aggregate infection reports from six epidemic seasons collected by the state health department and a subset of virological tests from a sentinel program at a general hospital in San Luis Potos'{i}, M'{e}xico. We interpret the results and make recommendations for future data collection strategies.
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Cites work
- scientific article; zbMATH DE number 50836 (Why is no real title available?)
- An Introduction to Stochastic Epidemic Models
- Bayesian forecasting and dynamic models.
- Bayesian inference for diffusion-driven mixed-effects models
- Delayed acceptance particle MCMC for exact inference in stochastic kinetic models
- How direct competition shapes coexistence and vaccine effects in multi-strain pathogen systems
- Inference for discretely observed stochastic kinetic networks with applications to epidemic modeling
- Inference for reaction networks using the linear noise approximation
- Learning about physical parameters: the importance of model discrepancy
- Quantifying intrinsic and extrinsic noise in gene transcription using the linear noise approximation: an application to single cell data
- Scalable Bayesian Inference for Coupled Hidden Markov and Semi-Markov Models
- Stochastic modelling for systems biology.
- The effect of cross-immunity and seasonal forcing in a multi-strain epidemic model
- The influence of immune cross-reaction on phase structure in resonant solutions of a multi-strain seasonal SIR model
- Tracking epidemics with google flu trends data and a state-space SEIR model
- Tracking the dynamics of pathogen interactions: modeling ecological and immune-mediated processes in a two-pathogen single-host system
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