Statistical shape analysis of brain arterial networks (BAN)

DOI10.1214/21-AOAS1536zbMATH Open1498.62216arXiv2007.04793OpenAlexW3041629860MaRDI QIDQ2154222FDOQ2154222

Authors: Xiaoyang Guo, Aditi Basu Bal, Tom Needham, Anuj Srivastava 

Publication date: 14 July 2022

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: Structures of brain arterial networks (BANs) - that are complex arrangements of individual arteries, their branching patterns, and inter-connectivities - play an important role in characterizing and understanding brain physiology. One would like tools for statistically analyzing the shapes of BANs, i.e. quantify shape differences, compare population of subjects, and study the effects of covariates on these shapes. This paper mathematically represents and statistically analyzes BAN shapes as elastic shape graphs. Each elastic shape graph is made up of nodes that are connected by a number of 3D curves, and edges, with arbitrary shapes. We develop a mathematical representation, a Riemannian metric and other geometrical tools, such as computations of geodesics, means and covariances, and PCA for analyzing elastic graphs and BANs. This analysis is applied to BANs after separating them into four components -- top, bottom, left, and right. This framework is then used to generate shape summaries of BANs from 92 subjects, and to study the effects of age and gender on shapes of BAN components. We conclude that while gender effects require further investigation, the age has a clear, quantifiable effect on BAN shapes. Specifically, we find an increased variance in BAN shapes as age increases.

Full work available at URL: https://arxiv.org/abs/2007.04793

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zbMATH Keywords

graph matchingstatistical shape analysisbrain artery networkgraph shape PCA

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10) Physiology (general) (92C30)

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Cited In (3)

• A Wasserstein-type distance for Gaussian mixtures on vector bundles with applications to shape analysis
• Tree-oriented analysis of brain artery structure
• On the addition and comparison of graphs labeled with stochastic variables: Learnable anatomical catalogs

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