Statistical shape analysis of brain arterial networks (BAN)

DOI10.1214/21-AOAS1536MaRDI QIDQ2154222zbMATH OpenOpenAlexFDO

Authors Xiaoyang Guo, Aditi Basu Bal, Tom Needham, Anuj Srivastava

Publication date 14 July 2022

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2007.04793

zbMATH Keywords

graph matchingstatistical shape analysisbrain artery networkgraph shape PCA

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10) Physiology (general) (92C30)

Abstract: Structures of brain arterial networks (BANs) - that are complex arrangements of individual arteries, their branching patterns, and inter-connectivities - play an important role in characterizing and understanding brain physiology. One would like tools for statistically analyzing the shapes of BANs, i.e. quantify shape differences, compare population of subjects, and study the effects of covariates on these shapes. This paper mathematically represents and statistically analyzes BAN shapes as elastic shape graphs. Each elastic shape graph is made up of nodes that are connected by a number of 3D curves, and edges, with arbitrary shapes. We develop a mathematical representation, a Riemannian metric and other geometrical tools, such as computations of geodesics, means and covariances, and PCA for analyzing elastic graphs and BANs. This analysis is applied to BANs after separating them into four components -- top, bottom, left, and right. This framework is then used to generate shape summaries of BANs from 92 subjects, and to study the effects of age and gender on shapes of BAN components. We conclude that while gender effects require further investigation, the age has a clear, quantifiable effect on BAN shapes. Specifically, we find an increased variance in BAN shapes as age increases.

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Cites work

• scientific article; zbMATH DE number 5668397 (Why is no real title available?)
• scientific article; zbMATH DE number 1324235 (Why is no real title available?)
• A discrete framework to find the optimal matching between manifold-valued curves
• A metric on shape space with explicit geodesics
• A principal component analysis for trees
• A quotient space formulation for generative statistical analysis of graphical data
• An eigendecomposition approach to weighted graph matching problems
• Assignment Problems and the Location of Economic Activities
• Computable Elastic Distances Between Shapes
• Functional and shape data analysis
• Geodesic PCA in the Wasserstein space by convex PCA
• Geodesic PCA versus Log-PCA of Histograms in the Wasserstein Space
• Graph-valued regression: prediction of unlabelled networks in a non-Euclidean graph space
• Phase-Amplitude Separation and Modeling of Spherical Trajectories
• Shape Manifolds, Procrustean Metrics, and Complex Projective Spaces
• Statistical analysis and modeling of the geometry and topology of plant roots
• Statistical shape analysis of simplified neuronal trees
• Statistical shape analysis. With applications in R
• Statistics on the Stiefel manifold: theory and applications
• Structure spaces
• The quadratic assignment problem
• The statistical theory of shape

Cited in

(3)

• On the addition and comparison of graphs labeled with stochastic variables: Learnable anatomical catalogs
• Tree-oriented analysis of brain artery structure
• A Wasserstein-type distance for Gaussian mixtures on vector bundles with applications to shape analysis

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