Functional random effects modeling of brain shape and connectivity
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Abstract: We present a statistical framework that jointly models brain shape and functional connectivity, which are two complex aspects of the brain that have been classically studied independently. We adopt a Riemannian modeling approach to account for the non-Euclidean geometry of the space of shapes and the space of connectivity that constrains trajectories of co-variation to be valid statistical estimates. In order to disentangle genetic sources of variability from those driven by unique environmental factors, we embed a functional random effects model in the Riemannian framework. We apply the proposed model to the Human Connectome Project dataset to explore spontaneous co-variation between brain shape and connectivity in young healthy individuals.
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Cited in
(5)- Nonparametric Bayes models of fiber curves connecting brain regions
- Statistical shape analysis of brain arterial networks (BAN)
- Discussion of LESA: Longitudinal Elastic Shape Analysis of Brain Subcortical Structures
- Functional random effects modeling of brain shape and connectivity
- Statistical modelling of brain morphological measures within family pedigrees
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