Nonparametric Bayes models of fiber curves connecting brain regions
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Publication:5208053
DOI10.1080/01621459.2019.1574582zbMATH Open1428.62485arXiv1612.01014OpenAlexW2962745512WikidataQ91709579 ScholiaQ91709579MaRDI QIDQ5208053FDOQ5208053
Authors: Zhengwu Zhang, Maxime Descoteaux, David Dunson 
Publication date: 15 January 2020
Published in: Journal of the American Statistical Association (Search for Journal in Brave)
Abstract: In studying structural inter-connections in the human brain, it is common to first estimate fiber bundles connecting different regions of the brain relying on diffusion MRI. These fiber bundles act as highways for neural activity and communication, snaking through the brain and connecting different regions. Current statistical methods for analyzing these fibers reduce the rich information into an adjacency matrix, with the elements containing a count of the number of fibers or a mean diffusion feature (such as fractional anisotropy) along the fibers. The goal of this article is to avoid discarding the rich functional data on the shape, size and orientation of fibers, developing flexible models for characterizing the population distribution of fibers between brain regions of interest within and across different individuals. We start by decomposing each fiber in each individual's brain into a corresponding rotation matrix, shape and translation from a global reference curve. These components can be viewed as data lying on a product space composed of different Euclidean spaces and manifolds. To non-parametrically model the distribution within and across individuals, we rely on a hierarchical mixture of product kernels specific to the component spaces. Taking a Bayesian approach to inference, we develop an efficient method for posterior sampling. The approach automatically produces clusters of fibers within and across individuals, and yields interesting new insights into variation in fiber curves, while providing a useful starting point for more elaborate models relating fibers to covariates and neuropsychiatric traits.
Full work available at URL: https://arxiv.org/abs/1612.01014
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Cited In (6)
- Bayesian Framework for Simultaneous Registration and Estimation of Noisy, Sparse, and Fragmented Functional Data
- Statistical analysis of trajectories of multi-modality data
- A nonstationary nonparametric Bayesian approach to dynamically modeling effective connectivity in functional magnetic resonance imaging experiments
- Bayesian regression with undirected network predictors with an application to brain connectome data
- Score-Driven Modeling of Spatio-Temporal Data
- Bayesian inference of high-dimensional, cluster-structured ordinary differential equation models with applications to brain connectivity studies
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