Fluctuations in transcription factor binding can explain the graded and binary responses observed in inducible gene expression

DOI10.1016/J.JTBI.2003.08.008MaRDI QIDQ2187455zbMATH OpenOpenAlexWikidataFDO

Authors Jason R. Pirone, T. C. Elston

Publication date 3 June 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2003.08.008

zbMATH Keywords

binary and graded responseinducible gene expressionstochastic model

Mathematics Subject Classification ID

Stochastic ordinary differential equations (aspects of stochastic analysis) (60H10) Biochemistry, molecular biology (92C40)

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Cites work

• A survey of numerical methods for stochastic differential equations
• Computational cell biology
• Handbook of stochastic methods for physics, chemistry and natural sciences.

Cited in

(9)

• Is the cell \textit{really} a machine?
• A feedforward loop motif in transcriptional regulation: induction and repression
• Transcriptional stochasticity in gene expression
• Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1
• Protein synthesis driven by dynamical stochastic transcription
• How the number of alleles influences gene expression
• A model of gene expression based on random dynamical systems reveals modularity properties of gene regulatory networks
• Retroactivity effects dependency on the transcription factors binding mechanisms
• Stochastic effects of multiple regulators on expression profiles in eukaryotes

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