Fluctuations in transcription factor binding can explain the graded and binary responses observed in inducible gene expression

DOI10.1016/J.JTBI.2003.08.008zbMATH Open1439.92088OpenAlexW1977771126WikidataQ44858468 ScholiaQ44858468MaRDI QIDQ2187455FDOQ2187455

Authors: Jason R. Pirone, T. C. Elston 

Publication date: 3 June 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2003.08.008

Recommendations

• Models of transcription factor binding: sensitivity of activation functions to model assumptions
• Fluctuations of mRNA distributions in multiple pathway activated transcription
• Binding of transcription factors adapts to resolve information-energy tradeoff
• Retroactivity effects dependency on the transcription factors binding mechanisms
• Transcription dynamics of inducible genes modulated by negative regulations
• The nonlinear dynamics and fluctuations of mRNA levels in cross-talking pathway activated transcription
• Transcriptional stochasticity in gene expression
• Transcriptional bursting diversifies the behaviour of a toggle switch: hybrid simulation of stochastic gene expression
• Decoding transcriptional regulatory interactions

zbMATH Keywords

stochastic modelbinary and graded responseinducible gene expression

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Stochastic ordinary differential equations (aspects of stochastic analysis) (60H10)

Cites Work

• A survey of numerical methods for stochastic differential equations
• Handbook of stochastic methods for physics, chemistry and natural sciences.
• Computational cell biology

Cited In (9)

• Protein synthesis driven by dynamical stochastic transcription
• A model of gene expression based on random dynamical systems reveals modularity properties of gene regulatory networks
• Is the cell \textit{really} a machine?
• How the number of alleles influences gene expression
• Transcriptional stochasticity in gene expression
• Retroactivity effects dependency on the transcription factors binding mechanisms
• Stochastic effects of multiple regulators on expression profiles in eukaryotes
• Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1
• A feedforward loop motif in transcriptional regulation: induction and repression

This page was built for publication: Fluctuations in transcription factor binding can explain the graded and binary responses observed in inducible gene expression

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2187455)