Sample size calculations for the differential expression analysis of RNA-seq data using a negative binomial regression model

DOI10.1515/SAGMB-2018-0021zbMATH Open1420.92087OpenAlexW2914372774WikidataQ91154025 ScholiaQ91154025MaRDI QIDQ2324965FDOQ2324965

Authors: Dongfeng Wu, Nigel G. F. Cooper, Shesh N. Rai, Xiaohong Li 

Publication date: 12 September 2019

Published in: Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1515/sagmb-2018-0021

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zbMATH Keywords

RNA-seqWald testsample sizepower analysisdifferentially expressed genes (DEGs)

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

Cites Work

• Title not available (Why is that?)
• A Direct Approach to False Discovery Rates
• The use of score tests for inference on variance components
• Small-sample estimation of negative binomial dispersion, with applications to SAGE data
• Inferences and power analysis concerning two negative binomial distributions with an application to MRI lesion counts data

Cited In (5)

• Asymptotic inversion of the binomial and negative binomial cumulative distribution functions
• The NBP negative binomial model for assessing differential gene expression from RNA-Seq
• No counts, no variance: allowing for loss of degrees of freedom when assessing biological variability from RNA-seq data
• Single-gene negative binomial regression models for RNA-seq data with higher-order asymptotic inference
• Sample size calculation based on generalized linear models for differential expression analysis in RNA-seq data

Uses Software

• DEseq

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