Layered decomposition for the model order reduction of timescale separated biochemical reaction networks

DOI10.1016/J.JTBI.2014.04.007MaRDI QIDQ2415563zbMATH OpenOpenAlexWikidataFDO

Authors Thomas P. Prescott, Antonis Papachristodoulou

Publication date 23 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2014.04.007

zbMATH Keywords

nonlinear ODEsreaction kineticssingular perturbation

Mathematics Subject Classification ID

Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A multi-time-scale analysis of chemical reaction networks. I: Deterministic systems
• Community Structure in Time-Dependent, Multiscale, and Multiplex Networks
• Eigenvector-based intergroup connection of low rank for hierarchical multi-agent dynamical systems
• Guaranteed error bounds for structured complexity reduction of biochemical networks
• scientific article; zbMATH DE number 49093 (Why is no real title available?)
• Mathematical biology. Vol. 1: An introduction.
• Michaelis-Menten kinetics at high enzyme concentrations
• Model reduction of multiple time scale processes in non-standard singularly perturbed form
• Retroactivity Attenuation in Bio-Molecular Systems Based on Timescale Separation

Cited in

(8)

• Balanced truncation for model reduction of biological oscillators
• Heineken, Tsuchiya and Aris: ``On the mathematical status of the pseudo-steady state hypothesis. A classic from Volume 1 of \textit{Mathematical Biosciences}
• Methods of model reduction for large-scale biological systems: a survey of current methods and trends
• Structured Projection-Based Model Reduction With Application to Stochastic Biochemical Networks
• Analytical singular value decomposition for a class of stoichiometry matrices
• A geometric method for model reduction of biochemical networks with polynomial rate functions
• Graph-based, dynamics-preserving reduction of (bio)chemical systems
• Model decomposition and reduction tools for large-scale networks in systems biology

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• GenLouvain

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