Modeling cell-to-cell spread of HIV-1 with logistic target cell growth

DOI10.1016/J.JMAA.2014.10.086MaRDI QIDQ2515142zbMATH OpenOpenAlexFDO

Authors Xiulan Lai, Xingfu Zou

Publication date 11 February 2015

Published in Journal of Mathematical Analysis and Applications (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jmaa.2014.10.086

zbMATH Keywords

cell-free virus spread cell-to-cell transfer Hopf bifurcation

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) Medical epidemiology (92C60) Epidemiology (92D30)

Review text

This paper considers a model of HIV-1 infection that includes both diffusion-limited cell-free virus transmission and cell-to-cell transfer. The model is a system of equations of the form \[ \begin{align*}{ {d T(t}) \over {dt} &= r T(t) \left(1 - {T(t) + \alpha T^*(t)} \over {T_M}\right) - \beta_1 T(t) V(t) - \beta_2 T(t) T^*(t),\cr {d T^*(t)} \over {dt} &= \beta_1 T(t) V(t) + \beta_2 T(t) T^*(t) - d_{T^*} T^*(t),\cr {d V(t)} \over {dt} &= \gamma T^*(t) - d_V V(t). }\end{align*} \] The authors obtain the reproduction number of the system, which is given by \[ {\mathcal R}_0 = {\mathcal R}_{01} + {\mathcal R}_{02},\quad {\mathcal R}_{01} = {{\beta_1 \gamma T_M} \over {d_{T^*} d_V}},\quad {\mathcal R}_{02} = {{\beta_2 T_M} \over {d_{T^*}}}. \] Here, \({\mathcal R}_{01}\) is determined by cell-free virus infection, while \({\mathcal R}_{02}\) is determined by cell-to-cell infection. Assuming logistic growth for target cells, the authors show that if the basic reproduction number is larger than one, then the infection can persist and the Hopf bifurcation can occur from the positive equilibrium within certain parameter ranges.

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