Optimal mutation rates in dynamic environments

DOI10.1006/BULM.2002.0314zbMATH Open1334.92276arXivphysics/0004042OpenAlexW2028224301WikidataQ49009510 ScholiaQ49009510MaRDI QIDQ253304FDOQ253304

Authors: Nigel Snoad, Martin Nilsson 

Publication date: 8 March 2016

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: In this paper we study the evolution of the mutation rate for simple organisms in dynamic environments. A model with multiple fitness coding loci tracking a moving fitness peak is developed and an analytical expression for the optimal mutation rate is derived. Surprisingly it turns out that the optimal mutation rate per genome is approximately independent of genome length, something that also has been observed in nature. Simulations confirm the theoretical predictions. We also suggest an explanation for the difference in mutation frequency between RNA and DNA based organisms.

Full work available at URL: https://arxiv.org/abs/physics/0004042

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zbMATH Keywords

mutationoptimal mutation raterandom fitnesssuperior gene sequences

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Cited In (25)

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