Optimal mutation rates in dynamic environments

DOI10.1006/BULM.2002.0314MaRDI QIDQ253304zbMATH OpenOpenAlexWikidataFDO

Authors Nigel Snoad, Martin Nilsson

Publication date 8 March 2016

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/physics/0004042

zbMATH Keywords

mutationoptimal mutation raterandom fitnesssuperior gene sequences

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: In this paper we study the evolution of the mutation rate for simple organisms in dynamic environments. A model with multiple fitness coding loci tracking a moving fitness peak is developed and an analytical expression for the optimal mutation rate is derived. Surprisingly it turns out that the optimal mutation rate per genome is approximately independent of genome length, something that also has been observed in nature. Simulations confirm the theoretical predictions. We also suggest an explanation for the difference in mutation frequency between RNA and DNA based organisms.

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• Mutation, Sexual Reproduction and Survival in Dynamic Environments
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• Fidelity drive: a mechanism for chaperone proteins to maintain stable mutation rates in prokaryotes over evolutionary time
• Two optimal mutation rates in obligate pathogens subject to deleterious mutation
• The interaction between mobile DNAs and their hosts in a fluctuating environment
• The optimal burst of mutation to create a phenotype
• Optimal mutation probability for genetic algorithms
• Dynamics of information and optimal control of mutation in evolutionary systems
• Estimating the optimal bottleneck ratio for experimental evolution: the burst-death model
• A quantitative study of the dynamics of adaptive mutation appearance
• A quasispecies on a moving oasis
• Optimal bacteriophage mutation rates for phage therapy
• Non-uniform mutation rates for problems with unknown solution lengths
• Mutation rate evolution in replicator dynamics
• Changing the pace of evolution
• Monotonicity of fitness landscapes and mutation rate control
• Modeling and optimization of populations subject to time-dependent mutation.
• Minimum of information distance criterion for optimal control of mutation rate in evolutionary systems
• Selection for mutational robustness in finite populations
• Evolutionarily rational mutations in structured populations
• Dynamics of escape mutants

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